Gastrointestinal stromal tumors: what do we know now?

@article{Corless2014GastrointestinalST,
  title={Gastrointestinal stromal tumors: what do we know now?},
  author={Christopher L . Corless},
  journal={Modern Pathology},
  year={2014},
  volume={27},
  pages={S1-S16}
}
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI tract, arising from the interstitial cells of Cajal, primarily in the stomach and small intestine. They manifest a wide range of morphologies, from spindle cell to epithelioid, but are immunopositive for KIT (CD117) and/or DOG1 in essentially all cases. Although most tumors are localized at presentation, up to half will recur in the abdomen or spread to the liver. The growth of most GISTs is driven by… CONTINUE READING

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