Gastrointestinal stromal tumors: what do we know now?

  title={Gastrointestinal stromal tumors: what do we know now?},
  author={Christopher L . Corless},
  journal={Modern Pathology},
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI tract, arising from the interstitial cells of Cajal, primarily in the stomach and small intestine. They manifest a wide range of morphologies, from spindle cell to epithelioid, but are immunopositive for KIT (CD117) and/or DOG1 in essentially all cases. Although most tumors are localized at presentation, up to half will recur in the abdomen or spread to the liver. The growth of most GISTs is driven by… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 41 extracted citations

Mitochondrial Complex II: At the Crossroads.

View 14 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 150 references

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and Modern Pathology

GD Demetri, P Reichardt, Y Kang

Gastrointestinal stromal tumors in a mouse model by targeted Modern Pathology

G Sommer, V Agosti, I Ehlers

Gastrointestinal stromal tumors of the jejunum and ileum: a Modern Pathology

M Miettinen, H Makhlouf, LH Sobin

Similar Papers

Loading similar papers…