Gastrointestinal satiety signals in humans — Physiologic roles for GLP-1 and PYY ?

@article{Beglinger2006GastrointestinalSS,
  title={Gastrointestinal satiety signals in humans — Physiologic roles for GLP-1 and PYY ?},
  author={Christoph Beglinger and Lukas P. Degen},
  journal={Physiology \& Behavior},
  year={2006},
  volume={89},
  pages={460-464}
}
Intestinal GLP-1 and satiation: from man to rodents and back
TLDR
The available evidence for intestinal GLP-1 is reviewed to fulfill a number of established empirical criteria for assessing whether a hormone inhibits eating by eliciting physiological satiation in man and rodents.
Gut induced biomarkers of appetite and satiety
TLDR
The findings indicate that the receptor is not alone responsible for peptide secretion; it is rather a complex interaction between different receptor mechanisms.
Gastrointestinal targets to modulate satiety and food intake
TLDR
The role of enteroendocrine cells in the gastrointestinal tract as chemoreceptors that sense intraluminal contents and induce changes in food intake through the release of signalling substances, such as satiety hormones is discussed.
Effect of glucagon-like peptide-1 receptor antagonism on appetite and food intake in healthy men.
TLDR
The effect of ex9-39 on PYY secretion supports an autoinhibitory feedback mechanism that controls L cell secretion; the effect on insulin and glucagon confirms the role of GLP-1 in glycemic control through its action on pancreatic α and β cells.
Ghrelin, CCK, GLP-1, and PYY(3-36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB.
TLDR
Gastric emptying, the detection of specific digestive products by small intestinal enteroendocrine cells, and synergistic interactions among different GI loci all contribute to the secretion of ghrelin, CCK, GLP-1, and PYY(3-36).
Neuroendocrine control of satiation
TLDR
This review is not comprehensive; rather, it discusses only what it considers the best-understood mechanisms of satiation, with a special focus on normally operating physiological mechanisms.
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TLDR
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