Gastrointestinal peptide hormones during postoperative ileus

  title={Gastrointestinal peptide hormones during postoperative ileus},
  author={Joseph J. Cullen and J. Chris Eagon and Dr. Keith A. Kelly},
  journal={Digestive Diseases and Sciences},
The hypothesis was that postoperative ileus might be caused by a disturbed balance between the motor-stimulating hormones, motilin and substance P, and the motorinhibitory hormone, vasoactive intestinal polypeptide, and that octreotide might prevent this disturbance and so ameliorate the ileus. In 15 conscious dogs with chronic gastro-intestinal electrodes, electrical activity was recorded and blood was drawn for radioimmunoassay of motilin, substance P, and vasoactive intestinal peptide (VIP… CONTINUE READING


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