Gastrointestinal oxalic acid absorption in calcium-treated rats

  title={Gastrointestinal oxalic acid absorption in calcium-treated rats},
  author={Makoto Morozumi and Rayhan Hossain and Kenichi Yamakawa and Sanehiro Hokama and Saori Nishijima and Yoshinori Oshiro and Atsushi Uchida and Kimio Sugaya and Yoshihide Ogawa},
  journal={Urological Research},
We studied whether urinary oxalate excretion after an acute oral load of oxalic acid is influenced by concomitant administration of calcium in rats. Male Wistar rats weighing approximately 180 g were divided into six groups of five animals each. After inducing anesthesia, the animals were orally (via a gastrostomy) given 110 μmol of oxalic acid along with 0, 27.5, 55, 110, or 220 μmol of calcium (0, 27.5, 55, 110, or 220 μmol Ca group, respectively). Saline was given to the control group… 

Influence of nutrition on feline calcium oxalate urolithiasis with emphasis on endogenous oxalate synthesis

The generally accepted dietary risk factors for CaOx urolithiasis in cats are discussed and a model for the biosynthetic pathways of oxalate in feline liver is provided and a low peroxisomal activity of AGT1 in cat liver is compatible with the view that felids utilised a low-carbohydrate diet throughout evolution.

Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats

Although the observed higher urinary volume is beneficial, the increase in urinary Ca concentrations, renal Ca and Ox excretion and urinary RSS CaOx associated with a high-protein diet may be critical for the development of CaOx uroliths in cats.

Effects of potassium chloride and potassium bicarbonate in the diet on urinary pH and mineral excretion of adult cats

The dietary inclusion of KHCO3 instead of KCl as K source could be beneficial for the prevention of CaOx urolith formation in cats, since there is an association between a lower renal Ca excretion and a generally higher urine pH.

Rating of Oxalate Ions of Various Fruits in Different Phases

The oxalate content of Beet, Sweet Potato, Tomato, Guava, Sapatofruits at different phases of raw, semi ripening and ripening were found out by permanganometric method. Oxalate rich foods are usually

Influence of protein concentration and quality in a canned diet on urine composition, apparent nutrient digestibility and energy supply in adult cats

A high protein canned diet might not be a specific risk factor for CaOx urolith formation in cats, and all diets resulted in high RSS MAP values, which might be critical concerning MAP crystallization.


A calculus (plural calculi), often called a stone, is a concretion of material, usually mineral salts, that forms in an organ or duct of the body. Formation of calculi is known as lithiasis. Stones

The health benefits of calcium citrate malate: a review of the supporting science.

Biological Functions and Anti-nutritional Effects of Phytochemicals in Living System

Nine of the common phytochemicals; flavonoids, cardiac glycosides, alkaloids, phytate, haemaglutinin, saponins, tannins, oxalate and phenols were reviewed to unveil its biological roles and its anti-nutritional instincts.

Phytochemical, proximate and elemental analysis of acalypha wilkesiana leaves

Acalypha wilkesiana,commonly called Irish petticoat, is native to the south pacific islands andbelongs to the family Euphorbiaceae. Apart from its use as a vegetable, theplant is also used in

Medicinal Potential of Acalypha wilkesiana Leaves

Background and Aim: Acalypha wilkesiana, commonly called Irish petticoat, is native to the south pacific islands and belongs to the family Euphorbiaceae. The plant has antimicrobial and antifungal



Milk and calcium prevent gastrointestinal absorption and urinary excretion of oxalate in rats.

It is demonstrated that calcium salt, or dairy products containing calcium (especially high-calcium low-fat milk) could decrease the gastrointestinal absorption and subsequent urinary excretion of oxalate.

Impact of dietary calcium and oxalate ratio on urinary stone formation in rats.

The bioavailability of dietary oxalate in rats depends mainly on the relative intestinal calcium level, and hyperoxaluria without hyperabsorption of calcium could be induced by oral administration of a relatively high-oxalate and low-calcium (Oxalate:calcium >1 [mol/mol]) diet.

Effect of dietary calcium on urinary oxalate excretion after oxalate loads.

Calcium and oxalic acid kinetics differ in rats.

Calcium and oxalic acid demonstrate different absorption and distribution kinetics in rats as a basis for studying calcium oxalate absorption and retention.

The stomach: a new and powerful oxalate absorption site in man.

Absorption of calcium oxalate does not require dissociation in rats.

Calcium bound as a small, neutral, calcium salt such as calcium oxalate does not have to be dissociated prior to absorption, and this results alter the current understanding of calcium bioavailability from foods and therapeutic agents.

Dependence of oxalate absorption on the daily calcium intake.

Two to 20% of ingested oxalate is absorbed in the gastrointestinal tract of healthy humans with a daily 800 mg calcium intake. Calcium is the most potent modifier of the oxalate absorption. Although

Effect of calcium intake on urinary oxalate excretion in calcium stone-forming patients.

It is suggested that a long-lasting regular calcium consumption <500 mg was not associated with high oxaluria and that a subpopulation of hypercalciuric patients who presented a higher intestinal calcium absorption (DDHC) tended to hyperabsorb oxalate as well, so thatOxaluria did not change under different calcium intake.

Contribution of dietary oxalate to urinary oxalate excretion.

It is suggested that dietary oxalate makes a much greater contribution to urinaryOxalate excretion than previously recognized, that dietary calcium influences the bioavailability of ingested oxalATE, and that the absorption of dietary oxAlate may be an important factor in calcium oxalates stone formation.

Relationships between calcium and oxalic acid intake in the diet and their excretion in the urine of normal and renal-stone-forming subjects.

The short-term effects of different intakes of calcium and oxalic acid on the urinary excretion of these substances was studied in eight normal men and eight men with a history of calcium-containing renal stones and there was a statistically significant fall in the calcium oxalate activity product in both the patients and normal subjects.