Gastrointestinal blood loss caused by controlled-release and conventional acetylsalicylic acid tablets.

@article{Brandslund1979GastrointestinalBL,
  title={Gastrointestinal blood loss caused by controlled-release and conventional acetylsalicylic acid tablets.},
  author={Ivan Brandslund and H. Rask and Niels Anders Klitgaard},
  journal={Scandinavian journal of rheumatology},
  year={1979},
  volume={8 4},
  pages={
          209-13
        }
}
Gastrointestinal blood loss has been studied following oral administration of the novel controlled-release acetylsalicylic acid tablet preparation Acetard and the instant-release acetylsalicylic acid tablet Magnecyl (Ph. Nord. 63). Acetard contains micro-encapsulated acetylsalicylic acid crystals having an in vitro release time of approximately 4 hours. The investigation was carried out as a two-part, randomized cross-over trial, and with a test dosage of either 1 g X 4 or 2 g X 2 per day… Expand
4 Citations
Fecal blood loss caused by two differently microencapsulated acetylsalicylic acid preparations in patients with rheumatoid arthritis. A prospective crossover study.
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In an investigator-blind crossover study, fecal blood loss determined by 51Cr-labelled red cells was measured in 17 male patients with rheumatoid arthritis and one with anchylosing spondylitis, with the exception of one patient, who suffered clinically significant bleeding. Expand
Systemic availability of acetylsalicylic acid in human subjects after oral ingestion of three different formulations.
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Concentrations found indicate that long-term antithrombotic therapy with ASA in a sustained release formulation may be possible, and indeed is possible, according to the present study. Expand
Comparison of three slow-release acetylsalicylic acid preparations in rheumatoid arthritis.
Nine patients suffering from chronic rheumatoid arthritis were each given single doses of 1 g acetylsalicylic acid, in the form of each of the preparations studied: an enteric-coated tablet, aExpand

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