Gastrointestinal blood loss caused by controlled-release and conventional acetylsalicylic acid tablets.

  title={Gastrointestinal blood loss caused by controlled-release and conventional acetylsalicylic acid tablets.},
  author={Ivan Brandslund and H. Rask and Niels Anders Klitgaard},
  journal={Scandinavian journal of rheumatology},
  volume={8 4},
Gastrointestinal blood loss has been studied following oral administration of the novel controlled-release acetylsalicylic acid tablet preparation Acetard and the instant-release acetylsalicylic acid tablet Magnecyl (Ph. Nord. 63). Acetard contains micro-encapsulated acetylsalicylic acid crystals having an in vitro release time of approximately 4 hours. The investigation was carried out as a two-part, randomized cross-over trial, and with a test dosage of either 1 g X 4 or 2 g X 2 per day… Expand
4 Citations
Fecal blood loss caused by two differently microencapsulated acetylsalicylic acid preparations in patients with rheumatoid arthritis. A prospective crossover study.
In an investigator-blind crossover study, fecal blood loss determined by 51Cr-labelled red cells was measured in 17 male patients with rheumatoid arthritis and one with anchylosing spondylitis, with the exception of one patient, who suffered clinically significant bleeding. Expand
Systemic availability of acetylsalicylic acid in human subjects after oral ingestion of three different formulations.
Concentrations found indicate that long-term antithrombotic therapy with ASA in a sustained release formulation may be possible, and indeed is possible, according to the present study. Expand
Comparison of three slow-release acetylsalicylic acid preparations in rheumatoid arthritis.
Nine patients suffering from chronic rheumatoid arthritis were each given single doses of 1 g acetylsalicylic acid, in the form of each of the preparations studied: an enteric-coated tablet, aExpand


Reduction or prevention of aspirin‐induced occult gastrointestinal blood loss in man
It is concluded that aspirin‐induced gastrointestinal bleeding is a local rather than a systemic effect under the experimental conditions. Expand
Acetylsalicylic acid and gastrointestinal bleeding measurement of blood loss using a modified radioactive chromium method.
A significant reduction in gastrointestinal bleeding was registered during ingestion of the buffered ASA in comparison with the plain ASA tablets, and no feces homogenization was necessary. Expand
Absorption of acetylsalicylic acid from unbuffered and buffered gastric contents
It was found that the buffered acetylsalicylate test meals were emptied more rapidly from the stomach than test meals containing unbuffered (pH 2.8) acetyl salicylic acid. Expand
A method of evaluation of the influence of aspirin formulations on gastrointestinal microbleeding in humans.
It was shown that treatment with aspirin may influence the fecal blood loss observed during the next period of treatment with a different aspirin formulation, so any cross-over study of aspirin-induced gastrointestinal microbleeding should be balanced for residual effects. Expand
Anti-inflammatory drugs and gastric mucus.
The gastric mucus in the rat was studied by a histochemical technique after administration of calcium acetylsalicylate, oxiphenbutazone, and indomethacin, and the results indicate that the effect on the gastric membranes is partly locally and partly generally induced. Expand
Anaemia in the elderly.
A study has been made of the haemoglobin levels of 475 people over the age of 65 living at home. Anaemia (Hb less than 12 g/100 ml) was commoner in women than men and increased in frequency with age.Expand
The Use of the Isotope 51Cr as a Label for Red Cells
It is evident that if labelling with 51Cr is to be used as a method of estimating red-cell lifespan, the rate at which chromium is eluted from red cells must be accurately defined. Expand
The role of acid in the pathogenesis of aspirin-induced gastrointestinal erosions and hemorrhage
  • A. R. Cooke
  • Medicine
  • The American journal of digestive diseases
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Gastric mucosa and susceptibility to occult gastrointestinal bleeding caused by aspirin.
It is still the opinion of the surgeons that surgical practice and the care of the patients was greatly superior to that in the old-style ward. Expand