Gastrointestinal and Hepatic Manifestations of Ebola Virus Infection

@article{Sharma2015GastrointestinalAH,
  title={Gastrointestinal and Hepatic Manifestations of Ebola Virus Infection},
  author={Nisha Sharma and Mitchell S. Cappell},
  journal={Digestive Diseases and Sciences},
  year={2015},
  volume={60},
  pages={2590-2603}
}
AimAlthough Ebola virus infection (EVI) clinically presents with common, prominent, gastroenterologic manifestations, this subject has not been previously reviewed. This work critically and comprehensively reviews this subject.MethodsThis study is a comprehensive literature review generated by computerized search of literature, supplemented by review of monographs and textbooks in pathology, gastroenterology, infectious diseases, and virology.ResultsCommon gastrointestinal manifestations… Expand
Ebola virus infection
TLDR
A severe, often fatal, zoonotic infection caused by a virus of the Filoviridae family (genus Ebolavirus); the lack of any specific antiviral treatment or approved vaccine makes treatment difficult. Expand
A CASE REPORT: RESPIRATORY MANIFESTATIONS OF COVID-19 STARTING WITH A GASTROINTESTINAL COMPLAINT: A COINCIDENCE OR A CORRELATION?
TLDR
A patient was proven to be suffering from COVID-19, and after hospitalization in the ICU for about 14 days, a recovery occurred and the patient was able to go home in a very good clinical condition. Expand
Relationship Between Viremia and Specific Organ Damage in Ebola Patients: A Cohort Study
  • S. Lanini, G. Portella, +44 authors C. Valdatta
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2018
TLDR
Evidence is provided to support that Ebola virus may have a direct role in muscular damage and imbalance of the coagulation system and to suggest that acute severe liver injury is not a typical feature of Ebola virus disease. Expand
Ebola and Marburg: Out of Africa
Ebola viruses and Marburg virus are zoonotic pathogens introduced into the human populations from close contact with infected animals from the rain forests of Central and West Africa and result inExpand
Ebola Virus: Overview, Genome Analysis and Its Antagonists
TLDR
After sequencing the Ebola virus genome, it has attracted the researchers, especially from Bioinformatics, Genomics, Transcriptomics, Proteomics and Metabolomics to analyze it and infer fruitful knowledge which can be used for efficient and robust drugs for EVD treatment approaches. Expand
Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells
TLDR
The data indicate that EBOV preferentially infects cells from the basolateral route, and this preference may be influenced by the resistance across the Caco-2 monolayer, which may be dependent on polarized distribution of heparan sulfate, a known viral attachment factor. Expand
Contrasting academic and lay press print coverage of the 2013-2016 Ebola Virus Disease outbreak
TLDR
It is suggested that comprehensive review articles could not serve as a source to clarify and contextualize the uncertainties around the EVD outbreak, perhaps due to adherence to technical accuracy at the expense of clarity within the context of outbreak conditions. Expand
Ebola outbreak in West Africa, 2014 and 2016: Epidemic timeline, differential diagnoses, determining factors and lessons for future response.
TLDR
A time-point health determinant model is brought up to conceptualize understanding of this important outbreak with a view to enlightening the public, and prospecting the future with valuable recommendations that may be crucial to preventing or urgently curtailing any future outbreak. Expand
Predictive Situation Awareness for Ebola Virus Disease using a Collective Intelligence Multi-Model Integration Platform: Bayes Cloud
TLDR
A computing system platform focusing on collective intelligence causal modeling, in order to support PSAW in the domain of infectious disease, and introduces one use case of predictive situation awareness for the Ebola virus disease. Expand
Equal authorship for equal authors: personal experience as an equal author in twenty peer-reviewed medical publications during the last three years.
  • M. Cappell
  • Medicine
  • Journal of the Medical Library Association : JMLA
  • 2016
TLDR
Standard medical indexes, such as PubMed or MEDLINE, uniformly list authors of publications in peer-reviewed journals sequentially, without provision for designating equal authorship for equal contributors, can discriminate against the second of equal authors, who is viewed as a lesser contributing author. Expand
...
1
2
...

References

SHOWING 1-10 OF 90 REFERENCES
Fulminant hepatitis: a clinical review of 11 years.
24 cases of fulminant hepatitis (FH) hospitalized in the Clínica de Doenças Infecciosas e Parasitárias do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo during the periodExpand
Firsthand clinical observations of hemorrhagic manifestations in Ebola hemorrhagic fever in Zaire.
  • P. Sureau
  • Medicine
  • Reviews of infectious diseases
  • 1989
TLDR
The hemorrhagic manifestations were less severe in the cases that occurred by the end of the outbreak than in the first reported cases, and less frequent and less severe, or even absent, in the nonfatal cases (convalescents, serologically confirmed). Expand
Fulminant hepatic failure in northern Brazil: morphological, immunohistochemical and pathogenic aspects of Lábrea hepatitis and yellow fever.
TLDR
In conclusion, midzonal apoptosis, portal phlebitis and a high proliferative index in patients without evidence of previous liver injury was the dominant picture in YF, whereas LH cases showed extensive, predominantly lytic hepatocytic necrosis, portal and hepatic vein phlebits and morula cells in patients with a morphological background of chronic liver disease. Expand
Histology of Symptomatic Acute Hepatitis C Infection in Immunocompetent Adults
TLDR
Early after acute hepatitis C viral infection,Biopsies can have a cholestatic pattern whereas later biopsies tend to show mild nonspecific portal and lobular lymphocytic inflammation, according to the time interval from clinical symptoms to biopsy. Expand
Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses
TLDR
The current state of knowledge of filovirus infections and their pathogenesis is discussed, including histopathological findings, epidemiology, modes of transmission and filov virus entry and spread within host organisms. Expand
Human infection due to Ebola virus, subtype Côte d'Ivoire: clinical and biologic presentation.
TLDR
No serologic conversion was detected among contact persons in Côte d'Ivoire or Switzerland, suggesting that infection-control precautions were satisfactory, and a new subtype of Ebola was isolated from the patient's blood on days 4 and 8. Expand
Cutaneous manifestations of filovirus infections
TLDR
Cutaneous manifestations rarely make a major contribution to disease severity but can assist with the diagnosis of fulminant hemorrhagic fever, and Rash, the main cutaneous disorder, is nonspecific and cannot guide the differential diagnosis. Expand
Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis.
TLDR
This review aims to provide an overview of EVD for clinicians, with the emphasis on pathogenesis, clinical manifestations, and treatment options. Expand
Clinical illness and outcomes in patients with Ebola in Sierra Leone.
TLDR
The incubation period and case fatality rate among patients with EVD in Sierra Leone are similar to those observed elsewhere in the 2014 outbreak and in previous outbreaks. Expand
A case of severe Ebola virus infection complicated by gram-negative septicemia.
TLDR
Intensive supportive treatment consisting of high-volume fluid resuscitation, broad-spectrum antibiotic therapy, and ventilatory support resulted in full recovery without the use of experimental therapies, suggesting that even severe EVD can be treated effectively with routine intensive care. Expand
...
1
2
3
4
5
...