Gastrointestinal alcohol dehydrogenase.

  title={Gastrointestinal alcohol dehydrogenase.},
  author={Helmut Karl Seitz and C M Oneta},
  journal={Nutrition reviews},
  volume={56 2 Pt 1},
Alcohol dehydrogenase (ADH) consists of a family of isozymes that convert alcohols to their corresponding aldehydes using NAD+ as a cofactor. The metabolism of ethanol by gastrointestinal ADH isozymes results in the production of acetaldehyde, a highly toxic compound that binds to cellular protein and DNA if not further metabolized to acetate by acetaldehyde dehydrogenase isozymes. Acetaldehyde seems to be involved in ethanol-associated cocarcinogenesis. The metabolism of retinol and the… CONTINUE READING


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