Gastrointestinal adverse events with sodium polystyrene sulfonate (Kayexalate) use: a systematic review.

BACKGROUND Sodium polystyrene sulfonate (Kayexalate; Sanofi-Aventis, Paris, France) is a cation-exchange resin routinely used in the management of hyperkalemia. However, its use has been associated with colonic necrosis and other fatal gastrointestinal adverse events. Although the addition of sorbitol to sodium polystyrene sulfonate preparations was… CONTINUE READING