Gastrointestinal absorption of drugs: methods and studies.

  title={Gastrointestinal absorption of drugs: methods and studies.},
  author={Laurence Barthe and John Woodley and Georges Houin},
  journal={Fundamental & clinical pharmacology},
  volume={13 2},
Physico-chemical descriptors of drug molecules are often not adequate in predicting their oral bioavailability. In vitro methods can be useful in evaluating some of the different factors contributing to bioavailability. While physical parameters such as drug solubility may effect oral bioavailability, in most cases, the major determining factors are likely to be metabolism, and absorption at the intestinal level. Metabolism may be preabsorptive, as with peptides, or during absorption… CONTINUE READING