Gastrointestinal absorption enhancement of insulin by administration of enteric microspheres and SNAC to rats.

@article{Qi2004GastrointestinalAE,
  title={Gastrointestinal absorption enhancement of insulin by administration of enteric microspheres and SNAC to rats.},
  author={Rong Qi and Qi Neng Ping},
  journal={Journal of microencapsulation},
  year={2004},
  volume={21 1},
  pages={37-45}
}
The preparation and characteristics of insulin enteric microspheres (EMS) were studied and the gastrointestinal absorption enhancement of insulin by co-administering EMS with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) was determined. The w/o/w and o(1)/o(2) emulsion solvent evaporation methods were used to prepare insulin-hydroxypropyl methylcellulose phthalate (HPMCP) EMS. High-performance liquid chormatography determined the drug loading, entrapment efficiency, stability to pepsin… CONTINUE READING