Gastrointestinal Stromal Tumors: Current Diagnosis, Biologic Behavior, and Management

  title={Gastrointestinal Stromal Tumors: Current Diagnosis, Biologic Behavior, and Management},
  author={Ihor Pidhorecky and Richard T. Cheney and William G. Kraybill and John F. Gibbs},
  journal={Annals of Surgical Oncology},
Gastrointestinal stromal tumors (GIST) are rare tumors of the gastrointestinal (GI) tract that arise from primitive mesenchymal cells. GISTs occur throughout the GI tract but are usually located in the stomach and small intestine. The majority of GISTs are immunohistochemically positive for c-kit protein (CD117) and CD34. GISTs express a heterogeneous clinical course not easily predicted by standard pathological means. The most important prognostic factors are size >5 cm, tumor necrosis… CONTINUE READING
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