Gastroesophageal reflux disease and asthma: an intriguing dilemma

@article{Astarita2000GastroesophagealRD,
  title={Gastroesophageal reflux disease and asthma: an intriguing dilemma},
  author={Corrado Astarita and Domenico Gargano and Marina Cutajar and A Napolitano and Francesco Manguso and Gabriella Abbate},
  journal={Allergy},
  year={2000},
  volume={55}
}
Background: Gastroesophageal reflux disease (GORD) is characterized by typical reflux symptoms and multiple atypical extraesophageal symptoms. Gastric asthma is a prominent extraesophageal manifestation of GORD. There is persistent debate about the pathophysiologic mechanisms triggering asthma by GOR. 
Clinical manifestations and complications of gastroesophageal reflux disease (GERD)
TLDR
The symptoms, diseases and complications in which the abnormal reflux of gastric content to the oesophagus and adjacent organ systems is believed to be a frequent contributory factor are addressed.
Gastro-esophageal reflux disease and poorly controlled asthma in pediatric population: are they linked? Effect of anti-reflux treatment
TLDR
Assessment of the prevalence of GERD in a group of moderate persistent or severe persistent asthma and the clinical response of asthma to anti-reflux treatment indicate a relationship between gastroesophageal reflux and asthma, patients with persistent asthma should be screened forReflux and receive treatment for better control of their asthma.
Asthma and gastroesophageal reflux in children: cause or effect? Current and novel approaches
TLDR
It is therefore pertinent that the clinician treating a child with ‘difficult’ asthma considers the possibility of GERD-related symptoms, and the use of the appropriate GERD monitoring and diagnostic tools can improve the morbidity and quality of life of this group.
Gastroesophageal reflux and asthma in childhood: a study on their relationship using esophageal PH monitoring Refluxo gastroesofágico e asma na infância: um estudo de sua relação através de monitoramento do pH esofágico
TLDR
The results of this study indicate a relationship between gastroesophageal reflux and asthma, and suggest that the reflux index as a single parameter of pH monitoring has good sensitivity and specificity in relation to asthma diagnosis.
Gastroesophageal reflux and asthma in childhood: a study on their relationship using esophageal PH monitoring.
TLDR
The results of this study indicate a relationship between gastroesophageal reflux and asthma, and suggest that the reflux index as a single parameter of pH monitoring has good sensitivity and specificity for the diagnosis of gastroeastern reflux disease.
Induced Sputum Substance P in Children with Difficult-to-Treat Bronchial Asthma and Gastroesophageal Reflux: Effect of Esomeprazole Therapy
TLDR
Very high ISSP levels in children with DA may be used as a marker for presence of GERD, and esomeprazole therapy improved asthma symptoms but did not improve lung function.
Protector mechanisms of the association between gastroesophageal reflux disease and asthma: experimental study in rats.
TLDR
The results highlight to the existence of a complex interaction between pulmonary allergy and gastric juice in the airways, and suggest that the reduced contractile response observed in vitro may represent a protector mechanism of the airway.
Omeprazole reduces the response to capsaicin but not to methacholine in asthmatic patients with proximal reflux
TLDR
In asthmatics, inhibition of gastric acid secretion does not influence bronchial hyperresponsiveness but decreases tussive sensitivity and this effect is related to proximal reflux, and omeprazole reduced asthma symptoms in patients with proximal or distal reflux.
A Comparison of Impulse Oscillometry and Spirometry Values in Patients with Gastroesophageal Reflux Disease
TLDR
Abnormal airway resistance may be present in GERD patients even when there is no obvious respiratory symptom, and oscillometry seems to be more sensitive than spirometry in reporting abnormal pulmonary function in patients with GERD.
Calcium and Magnesium in Exhaled Breath Condensate of Children with Endogenous and Exogenous Airway Acidification
TLDR
Lower concentration of magnesium in exhaled breath condensate of children with uncontrolled asthma and children with gastroesophageal reflux disease indicates that decreased total magnesium concentration may be found in EBCs, irrespective of whether the acidification is the result of endogenous pathomechanisms or reflux-induced mechanisms.
...
1
2
...

References

SHOWING 1-10 OF 46 REFERENCES
Gastroesophageal reflux and asthma: a possible reflex mechanism.
TLDR
The technique employed and the prompt reversal of pulmonary functions suggest reflex mechanisms may be producing the observed bronchoconstriction in asthmatic patients with gastroesophageal reflux.
Gastric asthma: a pathophysiological entity?
TLDR
Oesophageal pH-metry to prove GORD and gastroscopy to diagnose Barrett's metaplasia are advisable and selecting those who are likely to respond to anti-reflux measures is important: those with difficult to treat asthma, non-allergic asthma, adult-onset asthma with GORD.
Gastro-oesophageal reflux and triggering of bronchial asthma: a negative report.
TLDR
It is concluded that GO-reflux does not play an important role as an immediate trigger factor in bronchial asthma.
“Silent” Gastroesophageal Reflux: An Important but Little Known Cause of Pulmonary Complications
TLDR
It is concluded that all patients with pulmonary infection or disease of obscure etiology should be investigated for occult gastroesophageal reflux, and the same conclusion is reached regarding chronic nocturnal aspiration of gastric contents in the patient with an incompetent cardioesophileal junction.
Mechanisms for the association of gastroesophageal reflux and bronchospasm.
TLDR
The data support the view that microaspiration into the trachea may be an important mechanism for bronchospasm induced by gastroesophageal reflux and needs to be distinguished from simple reflux into the esophagus.
Oesophageal reflux and asthma.
TLDR
The effects on asthma following treatment of reflux has been anecdotally reported to be successful in some individuals, particularly those with severe reflux, but surgery should be reserved for individuals only after failure of medical treatment and should be aimed at improving reflux symptoms rather than improving asthma control.
The potential role of gastroesophageal reflux in the pathogenesis of food‐induced wheezing
TLDR
The case of a patient with severe asthma who had food allergy and gastroesophageal reflux whose clinical findings support the hypothesis that food allergens sensitize T cells in the peribronchial lymphoid tissue and induce the production of food‐specific IgE antibodies that sensitize airway cells.
Pulmonary symptoms associated with gastroesophageal reflux: use of ambulatory pH monitoring to diagnose and to direct therapy.
TLDR
Documenting abnormal gastroesophageal reflux helps direct appropriate therapy, and proximal pH monitoring may identify patients with pulmonary symptoms who respond to anti-reflux therapy.
Gastro-oesophageal reflux prevalence and relationship with bronchial reactivity in asthma.
TLDR
Data do not support a firm aetiological relationship between gastro-oesophageal reflux and asthma, but do suggest an association between the number of reflux episodes and bronchial hyperresponsiveness.
...
1
2
3
4
5
...