Gastroesophageal reflux disease, acid suppression, and Mycobacterium avium complex pulmonary disease.

@article{Thomson2007GastroesophagealRD,
  title={Gastroesophageal reflux disease, acid suppression, and Mycobacterium avium complex pulmonary disease.},
  author={Rachel M. Thomson and John G. Armstrong and David F. M. Looke},
  journal={Chest},
  year={2007},
  volume={131 4},
  pages={
          1166-72
        }
}
BACKGROUND Weekly symptoms of gastroesophageal reflux disease (GERD) occur in 20% of the population, and GERD has been implicated in the pathophysiology of many respiratory diseases. Microaspiration of contaminated water is a potential portal of entry for Mycobacterium avium complex (MAC) organisms into the respiratory tract, and acid-suppression therapy may enhance the survival of mycobacteria in the stomach. This study aimed to assess the prevalence of GERD, swallowing disorders, reflux… 
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94 Citations
Highly Influential Citations
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Methods Citations
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94 Citations

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Citation Type

[The Prevalence of Nontuberculous Mycobacterial Lung Disease with orwithout Reflux Esophagitis].
TLDR
Investigating the prevalence of GERD in accordance with the presence or absence of NTM lung disease showed a greater prevalence of RE minimal change in patients with NTM than those without NTM with statistical significance.
Gastro-oesophageal reflux disease and non-asthma lung disease
TLDR
Proton-pump inhibitors are the medications of choice for GERD; other interventions shown to reduce reflux are weight loss, elevation of the head of the bed and avoidance of recumbency after meals, but acid suppression therapy does not address non-acid reflux that may be important in disease pathogenesis in select patients, and lifestyle modifications often fail.
Increased risk of pulmonary tuberculosis in patients with gastroesophageal reflux disease.
  • Wen-Chien Fan, S. Ou, +8 authors C.‐J. Liu
  • Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2016
TLDR
Patients with GERD have a significantly increased risk of PTB within 1 year of GERD diagnosis, and exposure to PPIs is an independent predictor for PTB among patients withGERD.
Bronchiectasis: new findings in the pathogenesis and treatment of this disease
TLDR
Bronchiectasis is an under-appreciated cause of chronic lung disease in the USA and macrolide therapy and hyperosmolar agents hold promise.
Mycobacterium avium complex pulmonary disease: new epidemiology and management concepts.
TLDR
Individuals who have proven to be susceptible to MAC-related pulmonary disease should institute measures to reduce exposure to environmental sources of infection and assess the impact of such preventive strategies on the incidence of new infection and disease recurrence.
When and how to treat pulmonary non‐tuberculous mycobacterial diseases
Non‐tuberculous mycobacteria are ubiquitous environmental organisms that have been recognized as a cause of pulmonary infection for over 50 years. Traditionally patients have had underlying risk…
Mycobacterium avium Complex Disease.
  • C. Daley
  • Medicine
    Microbiology spectrum
  • 2017
TLDR
Treatment outcomes for many patients with Mycobacterium avium complex (MAC) disease remain suboptimal, so new drugs and treatment regimens are greatly needed.
Environmental risk factors for pulmonary Mycobacterium avium-intracellulare complex disease.
TLDR
Patients with pulmonary MAC disease had significantly more soil exposure than noninfected control patients, which suggests that environmental soil exposure is a likely risk factor for the development of pulmonaryMAC disease.
Nontuberculous mycobacterial pulmonary disease: an integrated approach beyond antibiotics
TLDR
An integrated approach, including risk factor prevention, management of comorbidities, nutritional evaluation and intervention and pulmonary rehabilitation, should be considered in the optimal management of nontuberculous mycobacterial pulmonary disease.
Nontuberculous mycobacterial lung infections in patients with eating disorders: plausible mechanistic links in a case series.
TLDR
Clinical and experimental evidence is discussed that low body weight and chronic vomiting with attendant jeopardy for aspiration, as seen in patients with eating disorders, may represent risk factors for NTM lung disease.
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