Gastroesophageal Reflux Disease and Airway Hyperresponsiveness:Mechanisms and Mediators Involved GERD and Asthma

  title={Gastroesophageal Reflux Disease and Airway Hyperresponsiveness:Mechanisms and Mediators Involved GERD and Asthma},
  author={Giuseppe Spaziano and Gioia Tartaglione and Teresa Palmira Russo and Luca Gallelli and Bruno D'Agostino},
  journal={Clinical and Experimental Pharmacology},
Gastroesophageal reflux disease (GERD) is clearly explained as the unintentional passage of stomach contents through the esophagus that takes place many times during the day both in children and in adults. GERD leads to symptoms of heartburn and regurgitation, these defined esophageal symptoms are in dichotomy with extraesophageal symptoms of GERD. These extra-esophageal symptoms include several respiratory manifestations that include chronic cough, bronchoconstriction and inflammation of… 
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