Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains.

@article{Fox2004GastroenteritisIN,
  title={Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains.},
  author={James G Fox and Arlin B. Rogers and Mark T. Whary and Zhongming Ge and Nancy S. Taylor and Sandy Xu and Bruce H Horwitz and Susan E. Erdman},
  journal={Infection and immunity},
  year={2004},
  volume={72 2},
  pages={1116-25}
}
Campylobacter jejuni continues to be a leading cause of bacterial enteritis in humans. However, because there are no readily available animal models to study the pathogenesis of C. jejuni-related diseases, the significance of potential virulence factors, such as cytolethal distending toxin (CDT), in vivo are poorly understood. Mice deficient in NF-kappaB subunits (p50(-/-) p65(+/-)) in a C57BL/129 background are particularly susceptible to colitis induced by another enterohepatic microaerobe… CONTINUE READING

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