Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats.

@article{Hsieh2007GastrodiaEM,
  title={Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats.},
  author={Ching-Liang Hsieh and Jyh-Jian Lin and Su-yin Chiang and Shan-Yu Su and Nou-ying Tang and Gaung-Geng Lin and I. Hwa Lin and Chung-Hsiang Liu and Chien-Yun Hsiang and Jaw-Chyun Chen and Tin-Yun Ho},
  journal={Journal of ethnopharmacology},
  year={2007},
  volume={109 2},
  pages={241-7}
}
Gastrodia elata (Orchidaceae) is a Chinese herb. Our previous study showed that Gastrodia elata is able to reduce epileptic seizures, oxygen free radicals, microglia activation, and apoptosis in kainic acid (KA)-treated rats. Activator protein 1 (AP-1) is involved in modulating the neuronal plasticity and apoptosis. Therefore, the aim of this study was to investigate the role of AP-1 in antiepileptic effect of Gastrodia elata. Gastrodia elata (0.5, 1.0g/kg) or valproic acid (VA, 250mg/kg) was… CONTINUE READING
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