Gastrodia elata Blume and its pure compounds protect BV-2 microglial-derived cell lines against β-amyloid: the involvement of GRP78 and CHOP.

@article{Lee2012GastrodiaEB,
  title={Gastrodia elata Blume and its pure compounds protect BV-2 microglial-derived cell lines against β-amyloid: the involvement of GRP78 and CHOP.},
  author={G Lee and Hyung-ryong Kim and Sang-Yong Han and Bidur Bhandary and Do-sung Kim and M. G. Kim and Byung-Ok So and Sun-Young Kim and Kyu-Sik Jo and Bo-Hee Lee and Hee-Nam Seo and Soo-wan Chae and Han-jung Chae},
  journal={Biological research},
  year={2012},
  volume={45 4},
  pages={403-10}
}
OBJECTIVES Gastrodia elata (GE) Blume (Orchidaceae) has been previously known for its therapeutic benefits against neurodegenerative diseases. Microglial activation and death have been implicated in the pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease. In this study, GE and its pure components, gastrodin and 4-hydroxybenzyl alcohol (4HBA), were applied to β-amyloid-induced BV2 mouse microglial cells. MATERIALS AND METHODS Cell viability was assessed by… CONTINUE READING

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References

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Showing 1-10 of 34 references

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

  • M WANG, YE R, E BARRON, P BAUMEISTER, C MAO, AS LEE
  • Cell Death Diff
  • 2010
1 Excerpt

Protective eff ects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells

  • AN H, IS KIM, +6 authors DK CHOI
  • J Ethnopharmacol
  • 2010

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