Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults.

@article{Chang2011GastrooesophagealRT,
  title={Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults.},
  author={Anne B. Chang and Toby J Lasserson and Justin Gaffney and Frances L Connor and Luke Albert Garske},
  journal={The Cochrane database of systematic reviews},
  year={2011},
  volume={1},
  pages={
          CD004823
        }
}
BACKGROUND Gastroesophageal reflux disease (GORD) is said to be the causative factor in up to 41% of adults with chronic cough. Treatment for GORD includes conservative measures (diet manipulation), pharmaceutical therapy (motility or prokinetic agents, H(2)-antagonist and proton pump inhibitors (PPI)) and fundoplication. OBJECTIVES To evaluate the efficacy of GORD treatment on chronic cough in children and adults with GORD and prolonged cough that is not related to an underlying respiratory… Expand

Paper Mentions

Chronic Cough Due to Gastroesophageal Reflux in Adults: CHEST Guideline and Expert Panel Report.
TLDR
Although lifestyle modifications and weight reduction may be beneficial in suspected reflux-cough syndrome, PPIs demonstrated no benefit when used in isolation, and physiological testing should be reserved for refractory patients being considered for antireflux surgery or for those in whom there is strong clinical suspicion warranting diagnostic testing. Expand
Respiratory manifestations of gastro-oesophageal reflux in children
TLDR
Evidence for the assessment of children with suspected extraoesophageal manifestations of GORD is scanty and longitudinal studies with long-term follow-up are urgently required. Expand
Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease.
TLDR
Evidence suggests that rigorous patient selection is necessary to identify patient populations likely to be responsive to antireflux therapy, using physiologically timed cough events during reflux testing, minimal patient exclusion because of presumptive alternative diagnoses, and appropriate power to detect a modest therapeutic gain. Expand
Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report
TLDR
Treatment for GERD should not be used when there are no clinical features of GERD; and pediatric GERD guidelines should be used to guide treatment and investigations. Expand
Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report.
TLDR
Treatment for GERD should not be used when there are no clinical features of GERD; and pediatric GERD guidelines should be used to guide treatment and investigations. Expand
Gastro-oesophageal reflux disease and non-asthma lung disease
TLDR
Proton-pump inhibitors are the medications of choice for GERD; other interventions shown to reduce reflux are weight loss, elevation of the head of the bed and avoidance of recumbency after meals, but acid suppression therapy does not address non-acid reflux that may be important in disease pathogenesis in select patients, and lifestyle modifications often fail. Expand
Republished: Failure of reflux inhibitors in clinical trials: bad drugs or wrong patients?
TLDR
From the clinical data available, the best treatment results and, hence, the patients most likely to benefit from reflux inhibitors, are those with persistent reflux, most commonly manifest as persistent regurgitation despite PPI treatment. Expand
Failure of reflux inhibitors in clinical trials: bad drugs or wrong patients?
TLDR
From the clinical data available, the best treatment results and, hence, the patients most likely to benefit from reflux inhibitors, are those with persistent reflux, most commonly manifest as persistent regurgitation despite PPI treatment. Expand
Gastroesophageal Reflux in Chronic Cough and Cough Syncope and the Effect of Antireflux Treatment
TLDR
In treating well-selected GER-related chronic cough and cough syncope, PPI, SRF, and LF can be considered and satisfactory restoration of physical and social functions could be achieved after effective antireflux therapy. Expand
Should Acid Suppressive Therapy Improve Chronic Cough? (Chest 2013;143:605-612)
  • J. Oh
  • Medicine
  • Journal of neurogastroenterology and motility
  • 2013
TLDR
A therapeutic benefit for acid suppressive therapy in patients with chronic cough cannot be dismissed, and it would be much more effective in selective patients who are favorable to therapy based on symptoms or reflux testing. Expand
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