Gastrinomas: Advances in Diagnosis and Management

@article{Jensen2004GastrinomasAI,
  title={Gastrinomas: Advances in Diagnosis and Management},
  author={Robert T. Jensen},
  journal={Neuroendocrinology},
  year={2004},
  volume={80},
  pages={23 - 27}
}
  • R. Jensen
  • Published 1 October 2004
  • Medicine
  • Neuroendocrinology
Gastrinomas causing Zollinger-Ellison syndrome (ZES) are the most common functional, malignant pancreatic endocrine tumors. In this paper, the diagnosis and treatment of these tumors are reviewed, incorporating recent advances in each area. Furthermore, recent advances in their pathology, molecular pathogenesis, and aspects of their localization using somatostatin receptor scintigraphy, as well as their treatment are discussed. Recent data from our NIH prospective studies on patients with ZES… 

[Endocrine tumors of the stomach and duodenum (including gastrinoma) - management guidelines (recommended by the Polish Network of Neuroendocrine Tumors)].

TLDR
Polish guidelines for biochemical, pathological and localisation diagnosis, and therapeutic approaches, considering endoscopic and surgical treatment, pharmacological and radionuclide therapy are presented.

Duodenal gastrinoma treated with endoscopic band ligation.

Tumor Detection in Syndromic NET: Zollinger-Ellison Syndrome

TLDR
A 40-year-old female, presented with recurrent epigastric pain and acid reflux, uncontrolled with proton pump inhibitors is presented with a MEN1-related ZES, hypothesized on the basis of early age of onset and the evidence of multifocal tumors within the pancreas and duodenum.

Zollinger–Ellison Syndrome: Diagnosis and Management

TLDR
The management of ZES falls into two categories: the control of gastric acid hypersecretion and its clinical manifestations through the use of proton-pump inhibitors and the management of the tumor itself.

Answer Wermer Syndrome and Zollinger-Ellison Syndrome

  • Medicine
  • 2009
TLDR
A novel technique is presented that uses a lowdensity, barium-based oral contrast agent during the arterial phase of intravenous contrast–enhanced spiral CT of the abdomen that allows preoperative confirmation of multiple duodenal tumors, which influenced surgical planning.

Surgery for gastrinoma.

[Pancreatic endocrine tumors - management guidelines (recommended by the Polish Network of Neuroendocrine Tumors)].

TLDR
These guidelines refer to biochemical and location diagnostics, including scintygraphy of somatostatin receptors, endoscopic ultrasonography and other anatomical and functional imaging methods, which determines further management of patients with PETs.

Pancreatic islet cell carcinoma presenting with concurrent Cushing's and Zollinger-Ellison syndromes: case series and literature review.

Cushing's syndrome and Zollinger-Ellison syndrome occur occasionally as a result of neuroendocrine cancers. The concurrence of the two syndromes has been considered to confer a poor clinical and

Long-term suppressive effect of octreotide on progression of metastatic gastrinoma with multiple endocrine neoplasia type 1: seven-year follow up.

TLDR
The case of a 30-year-old woman with a history of prolactinoma and primary hyperparathyroidism suggests the importance of investigating the Ki67/MIB1 index and SSTR expression in patients with metastatic gastrinoma.

Sporadic duodenal macrogastrinoma: a rare case report

TLDR
This case is unique as duodenal gastrinomas are usually very small, up to 1 cm, and during the follow up period the etiology of slowly decreasing hypergastrinemia remains unclear, controversial and is under investigation.

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TLDR
The aims of the study were to evaluate the sensitivity of proposed acid secretory criteria for the diagnosis of ZES, propose new criteria, evaluate the variability and methodology of gastric secretory testing, and correlate the symptoms and signs of Zes, tumor extent, and primary tumor size and location with the degree of Gastric acid hypersecretion.

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TLDR
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TLDR
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