Gastrinoma (Duodenal and Pancreatic)

@article{Jensen2006GastrinomaA,
  title={Gastrinoma (Duodenal and Pancreatic)},
  author={Robert T. Jensen and Bruno Niederle and E. Mitry and John K. Ramage and Th. Steinm{\"u}ller and Valerie Lewington and Aldo Scarpa and Anders Sundin and Aurel Perren and David Gross and Juan Manuel O'Connor and Stanislas A. Pauwels and G{\"u}nter Kl{\"o}ppel},
  journal={Neuroendocrinology},
  year={2006},
  volume={84},
  pages={173 - 182}
}
a Digestive Diseases Branch, NIH, Bethesda, Md. , USA; b Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna , Austria; c Department of Hepatology and Gastroenterology, CHV A Pare Hospital, Boulogne , France; d Department of Gastroenterology, North Hampshire Hospital, Hampshire , UK; e Department of Surgery, Vivantes Humboldt Hospital, Berlin , Germany; f Department of Radiology, Royal Marsden Hospital, Sutton , UK; g Department of Pathology, Verona… 

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This work presents a meta-modelling study of the immune system’s role in the development of central giant cell granuloma, which is a type of cancer that is difficult to treat with conventional chemotherapy.

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References

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Location, incidence, and malignant potential of duodenal gastrinomas.

The data suggest that a single duodenal wall gastrinoma is a common cause of Zollinger-Ellison syndrome and these small tumors are located in the submucosal layer of the proximal duodenum and are malignant more often than previously thought.

Surgical pathology of gastrinoma. Site, size, multicentricity, association with multiple endocrine neoplasia type 1, and malignancy

Results suggest that duodenal location and multicentricity of gastrinomas are associated with the MEN‐1 syndrome, and solitary gastrinoma, either in the pancreas or the duodenum, are predominantly seen in sporadic ZES.

A Prospective Study of Intraoperative Methods to Diagnose and Resect Duodenal Gastrinomas

It is demonstrated that the duodenum is the most common location for gastrinoma in patients with ZES and that DX to detect and remove duodenal gastrinomas should be routinely performed in all explorations for patients withZES.

Pathologic aspects of gastrinomas in patients with Zollinger-Ellison syndrome with and without multiple endocrine neoplasia type I

In this review, the experience with the pathology of immunocytochemically identified gastrinomas in 44 patients with ZES is presented and related to the relevant literature.

Does the Use of Routine Duodenotomy (DUODX) Affect Rate of Cure, Development of Liver Metastases, or Survival in Patients With Zollinger-Ellison Syndrome?

These results demonstrate that routine use of DUODX increases the short-term and long-term cure rate due to the detection of more duodenal gastrinomas, and should be routinely performed during all operations for cure of sporadic ZES.

Gastrinomas: localization by means of selective intraarterial injection of secretin.

Selective IAS injection, combined with angiography, is the most sensitive study for localizing gastrinomas and avoids percutaneous transhepatic catheterization for portal venous sampling.

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Endocrine tumours of the gastrointestinal tract. Transplantation in the management of metastatic endocrine tumours.

Prospective study of the use of intraarterial secretin injection and portal venous sampling to localize duodenal gastrinomas.

Intraarterial secretin injection is more sensitive than PVS at localizing duodenal gastrinomas and should replace PVS in patients with ZES and occult tumors.
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