Gastrin-releasing peptide, immune responses, and lung disease.

  title={Gastrin-releasing peptide, immune responses, and lung disease.},
  author={Simone Degan and G Y L{\'o}pez and Katharine A. Kevill and Mary E. Sunday},
  journal={Annals of the New York Academy of Sciences},
Gastrin-releasing peptide (GRP) is produced by pulmonary neuroendocrine cells (PNECs), with highest numbers of GRP-positive cells present in fetal lung. Normally GRP-positive PNECs are relatively infrequent after birth, but PNEC hyperplasia is frequently associated with chronic lung diseases. To address the hypothesis that GRP mediates chronic lung injury, we present the cumulative evidence implicating GRP in bronchopulmonary dysplasia (BPD), the chronic lung disease of premature infants who… CONTINUE READING