Gastrin releasing peptide, but not pentagastrin, stimulates ACTH and cortisol secretion in conscious dogs

  title={Gastrin releasing peptide, but not pentagastrin, stimulates ACTH and cortisol secretion in conscious dogs},
  author={L. Sander and Ronald M. Thomas},
  journal={Regulatory Peptides},
Gastrin releasing peptide (GRP) is the mammalian equivalent of bombesin. Bombesin has been shown to stimulate canine ACTH and cortisol secretion in a dose-related manner. In the present study, following a 30-40 min saline infusion, a progressively-increasing, stepwise infusion of GRP (60, 600, 1200 pmol/kg per h) or pentagastrin (PG) (2, 4, 8 micrograms/kg per h) was administered. Each drug dose was infused for 40-45 min and blood samples were drawn at 20-22.5 min intervals. GRP caused… Expand
9 Citations
Possible role of cholecystokinin-A receptors in regulation of thyrotropin (TSH) secretion in male rats
The results probably indicate that CCK-A receptor stimulation inhibits TSH secretion at the level of the anterior pituitary gland, and PRL levels in male rats are not affected by CCK system. Expand
Bombesin Regulation of Adrenocorticotropin Release From Ovine Anterior Pituitary Cells
It is shown that although bombesin cannot stimulate ACTH secretion alone, it potentiates release by ovine CRF, an effect blocked by the GRP receptor antagonist D-Tyr6bombesin (6-13) propylamide. Expand
Anorectic action of bombesin requires receptor for corticotropin-releasing factor but not for oxytocin.
The present experiments support the contention that bombesin partly mediates its feeding-suppressant effects through interactions with CRF, and the specificity of this interaction is supported by the lack of interaction betweenBombesin and/or CRF with oxytocin. Expand
Effects of neurotensin and bombesin on the secretory and proliferative activity of regenerating rat adrenal cortex.
Findings allow us to draw the following conclusions: 1) endogenous NT and BM-like peptides influence adrenocortical regeneration in rats; 2) NT exerts a tonic inhibitory action on both aldosterone and corticosterone secretion, without affecting cell-proliferation rate; and 3) BM- like peptides exert a tonics suppressive effect on cortic testosterone production, coupled with a clear-cut stimulating effect on cell proliferation. Expand
Investigations on the acute effects of neuropeptides on the pituitary-adrenocortical function in normal and cold-stressed rats. II. Neurotensin and neuromedin N.
The effects of a subcutaneous bolus injection of neurotensin (NT) or neuromedin N (NMN) on the function of the hypothalamo-pituitary-adrenocortical axis were investigated in both normal and cold-stressed rats and the evident lack of correlation between the levels of circulating ACTH and the plasma concentrations of the main adrenal steroid hormones was suggested. Expand
Role of bombesin-related peptides in the mediation or integration of the stress response
Evidence presented suggests that BN-LPs mediate their stress-relevant effects through activation of CRH and/or AVP neurons, and several hypothetical mechanisms for such peptidergic interactions are discussed. Expand
Effects of bombesin and neuromedin-B on the proliferative activity of the rat adrenal cortex.
Findings indicate that BM and NMB enhance the proliferative activity of rat adrenocortical cells acting via different receptors or different mediators. Expand
Effects of bombesin on the morphology and function of the rat adrenal cortex: comparison of the acute and chronic responses.
It is suggested that the conspicuous stimulation of adrenocortical-cell proliferation evoked by BM infusion may be responsible for the apparent lack of effect of this treatment on B secretion. Expand
Effects of bombesin on the morphology and function of the rat adrenal cortex : comparison of the acute and chronic responses
The acute and chronic effects of bornbesin (BM) on the structure and function of rat adrenal cortex were investigated by rnorphornetric and radioirnrnunological techniques. An intraperitoneal bolusExpand


Influence of CCK and bombesin on ACTH and cortisol secretion in the conscious dog
Bombesin caused significant, dose-dependent increases in plasma cortisol and plasma ACTH and CCK-8 had no consistent effect on either cortisol or ACTH secretion. Expand
The effect of atropine on bombesin and gastrin releasing peptide stimulated gastrin, pancreatic polypeptide and neurotensin release in man
Despite structural homology, bombesin and GRP at the dose used are dissimilar in man in their actions and sensitivity to cholinergic blockade. Expand
Influence of bombesin, CCK, secretin and CRF on corticosterone concentration in the rat
Findings indicate that both CCK and bombesin cause pituitary-adrenal activation which may be related to the response of this system to food ingestion. Expand
Effect of porcine gastrin releasing peptide on gastric secretion and motility and the release of hormonal peptides in conscious cats
Gastrin release, elicited by the lowest ED50 of both BBS and GRP, should be considered as their primary effect in the cat, and according to the different targets studied, BBS was 4 to 9 times more potent thanGRP, 6 to 200 times more than PG. Expand
Effects of sham feeding, bethanechol, and bombesin on somatostatin release in dogs.
These studies show that sham feeding and bombesin release somatostatin, and suggest that som atostatin release is largely under vagal-cholinergic control. Expand
Comparative effects of bombesin and porcine gastrin-releasing peptide in the dog
The demonstration of equimolar potency of porcine GRP and bombesin support the concept that GRP is mammalian bombsin, and no significant difference in potency in changing gastric acid output, serum gastrin, and pancreatic polypeptide was observed. Expand
Effect of pentagastrin on adrenocorticotropin hormone and thyroid-stimulating hormone release in normal subjects.
Preliminary results suggest that gastrin can influence basal activity of ACTH-cortisol axis, but further investigation is required to determine its physiological role and mechanisms of action. Expand
Suppressive effect of pentagastrin on pituitary-adrenocortical secretion.
In in vitro incubation of rat pituitary tissue the addition of pentagastrin elicited a suppressive effect on the ACTH release from the tissue into the medium, and it was suggested that gastrin-like peptide might control the secretion of ACTH. Expand
Corticotrophin-releasing factor--mediated adrenocorticotrophin release from rat anterior pituitary cells is potentiated by C-terminal gastrin-releasing peptide.
An investigation of the effects of synthetic C-terminal gastrin-releasing peptide (GRP(14-27] on ACTH release from isolated rat anterior pituitary cells) potentiated the CRF-mediated in-vitro release of ACTH. Expand
A qualitative comparison of canine plasma gastroenteropancreatic hormone responses to bombesin and the porcine gastrin-releasing peptide (GRP)
The effect on plasma gastroenteropancreatic hormone levels on infusing the porcine gastrin-releasing peptide and bombesin into dogs demonstrated no qualitative difference in the spectrum of activity, and the similar spectrum of activities and the structural homology between the two peptides suggests that the Porcine Gastrin releasing peptide is the porCine counterpart of the amphibian peptide bombsin. Expand