Gastrin releasing peptide, but not pentagastrin, stimulates ACTH and cortisol secretion in conscious dogs

@article{Sander1991GastrinRP,
  title={Gastrin releasing peptide, but not pentagastrin, stimulates ACTH and cortisol secretion in conscious dogs},
  author={L. Sander and Ronald M. Thomas},
  journal={Regulatory Peptides},
  year={1991},
  volume={35},
  pages={127-133}
}
Gastrin releasing peptide (GRP) is the mammalian equivalent of bombesin. Bombesin has been shown to stimulate canine ACTH and cortisol secretion in a dose-related manner. In the present study, following a 30-40 min saline infusion, a progressively-increasing, stepwise infusion of GRP (60, 600, 1200 pmol/kg per h) or pentagastrin (PG) (2, 4, 8 micrograms/kg per h) was administered. Each drug dose was infused for 40-45 min and blood samples were drawn at 20-22.5 min intervals. GRP caused… Expand
9 Citations
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Evidence presented suggests that BN-LPs mediate their stress-relevant effects through activation of CRH and/or AVP neurons, and several hypothetical mechanisms for such peptidergic interactions are discussed. Expand
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Effects of bombesin on the morphology and function of the rat adrenal cortex : comparison of the acute and chronic responses
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