Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis.

@article{Koh2000GastrinIA,
  title={Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis.},
  author={Theodore J Koh and Clemens J. Bulitta and John V Fleming and Graham J. Dockray and Andrea Varr{\'o} and Timothy C Wang},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 4},
  pages={533-9}
}
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene occur in most colorectal cancers and lead to activation of beta-catenin. Whereas several downstream targets of beta-catenin have been identified (c-myc, cyclin D1, PPARdelta), the precise functional significance of many of these targets has not been examined directly using genetic approaches. Previous studies have shown that the gene encoding the hormone gastrin is activated during colon cancer progression and the less… CONTINUE READING