Gastrin-induced apoptosis contributes to carcinogenesis in the stomach

  title={Gastrin-induced apoptosis contributes to carcinogenesis in the stomach},
  author={Guanglin Cui and Shigeo Takaishi and Wandong Ai and Kelly S. Betz and Jon Florholmen and Theodore J Koh and Jeanmarie Houghton and D Mark Pritchard and Timothy C Wang},
  journal={Laboratory Investigation},
Hypergastrinemia in INS-GAS mice leads to accelerated carcinogenesis of the stomach, but the mechanisms have not been well defined. We investigated the possible role of gastrin-induced gastric cell apoptosis in the development of gastric cancer. We examined apoptosis and the expression of Bcl-2 family proteins in INS-GAS mice of different ages, as well as in gastrin-deficient (GAS-KO) mice after gastrin-17 (G-17) infusion. In addition, we studied the effects of the gastrin/cholecystokinin-2… CONTINUE READING


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Molecular characterization of rat gastric mucosal response to potent acid inhibition

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