Gastrin and D1 dopamine receptor interact to induce natriuresis and diuresis.

@article{Chen2013GastrinAD,
  title={Gastrin and D1 dopamine receptor interact to induce natriuresis and diuresis.},
  author={Yue Chen and Laureano D. Asico and Shuo Zheng and Van Anthony M. Villar and Duofen He and Lin Zhou and Chunyu Zeng and Pedro A. Jos{\'e}},
  journal={Hypertension},
  year={2013},
  volume={62 5},
  pages={927-33}
}
Oral NaCl produces a greater natriuresis and diuresis than the intravenous infusion of the same amount of NaCl. Gastrin is the major gastrointestinal hormone taken up by renal proximal tubule (RPT) cells. We hypothesized that renal gastrin and dopamine receptors interact to synergistically increase sodium excretion, an impaired interaction of which may be involved in the pathogenesis of hypertension. In Wistar-Kyoto rats, infusion of gastrin induced natriuresis and diuresis, which was abrogated… CONTINUE READING
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