Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells

Abstract

Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, characterized by excessive cell proliferation, resistance to apoptosis, and invasiveness. Due to resistance to currently available treatment options, the prognosis for patients with GBM is very dismal. The activation of gastrin-releasing peptide receptors (GRPR) stimulates GBM cell… (More)
DOI: 10.1007/s12035-016-9696-6

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