Gastric vagal afferent modulation by leptin is influenced by food intake status.

@article{Kentish2013GastricVA,
  title={Gastric vagal afferent modulation by leptin is influenced by food intake status.},
  author={Stephen J. Kentish and Tracey A O'donnell and Nicole J. Isaacs and Richard L Young and Hui Li and Andrea M. Harrington and Stuart M Brierley and Gary A Wittert and L Ashley Blackshaw and Amanda J. Page},
  journal={The Journal of physiology},
  year={2013},
  volume={591 7},
  pages={1921-34}
}
Energy intake is strongly influenced by vagal afferent signals from the stomach, and is also modulated by leptin. Leptin may be secreted from gastric epithelial cells, so we aimed to determine the direct effect of leptin on gastric vagal afferents under different feeding conditions. Female C57BL/6 mice were fed standard laboratory diet, high-fat diet or were food restricted. The expression of leptin receptor (Lep-R) and its signal transduction molecules in vagal afferents was determined by… CONTINUE READING