Gastric secretion

  title={Gastric secretion},
  author={Mitchell L. Schubert},
  journal={Current Opinion in Gastroenterology},
  • M. Schubert
  • Published 1 November 2014
  • Biology, Medicine
  • Current Opinion in Gastroenterology
Purpose of review This review summarizes the past year's literature regarding the neural, paracrine, hormonal, and intracellular regulation of gastric acid secretion. Recent findings Gastric acid facilitates the digestion of protein as well as the absorption of iron, calcium, vitamin B12, and certain medications. High gastric acidity, in combination with pepsin and lipase, kills ingested microorganisms and may play a role in preventing bacterial overgrowth, enteric infection, and possibly… 


The regulation of gastric acid secretion – clinical perspectives
It is remarkable that the interaction between Hp and gastrin may explain the pathogenesis of most diseases in the upper gastrointestinal tract.
H. pylori acutely inhibits gastric secretion by activating CGRP sensory neurons coupled to stimulation of somatostatin and inhibition of histamine secretion.
Acute administration of H. pylori is capable of inhibiting acid secretion directly as well as indirectly by activating intramural CGRP sensory neurons coupled to stimulation of SST and inhibition of histamine secretion.
Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation.
The available data on the expression of ghrelin in H. pylori infection is reviewed and how the defective gh Relin synthesis may contribute to sustain the ongoing inflammatory response in this disease is discussed.
Simultaneous detection of gastric acid and histamine release to unravel the regulation of acid secretion from the guinea pig stomach.
Under stimulated conditions with ACh, the gastrin and histamine components of the total acid secretion were not altered compared with levels observed under basal conditions, suggestive that ACh had no direct effect on the enterochromaffin-like cell and G cell.
Gastrin mediated down regulation of ghrelin and its pathophysiological role in atrophic gastritis.
  • T. Rau, A. Sonst, P. Konturek
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2013
This work aimed to examine the morphological changes in ghrelin expression under several inflammatory, metaplastic and carcinogenic conditions of the upper gastrointestinal tract and found evidence for a physiological interaction between gastrin and gh Relin in a primary rodent cell culture model.
Effects of Proton Pump Inhibitor Therapy in the Distal Gut: Putting the Pieces Together
Understanding the uncertainties surrounding long-term PPI use is particularly important at present given the general increase in PPIuse in recent years, both from the prescription of PPIs by physicians and the self-diagnosis and treatment that has resulted from the over-the-counter availability of the drugs.
Glycine-extended gastrin enhances somatostatin release from cultured rabbit fundic D-cells
The effect of G-Gly and gastrin on the release of somatostatin from rabbit fundic D-cells was examined and significantly enhanced subsequent basal as well as CCK- and GLP-1-stimulated som atostatin release.
Gastric acid secretion in experimental acute uremia.
In conclusion, acute renal failure promotes gastric acid hypersecretion that could potentially be attributed to high levels of gastrin hormone and uremic state per se.
Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight.
A growing body of evidence suggests that dysregulation in some of the components of the ghrelin system can lead to or influence the development and/or progression of highly concerning pathologies such as endocrine-related tumors, inflammatory/cardiovascular diseases, and neurodegeneration.
Characterization of gastrins and their receptor in solid human gastric adenocarcinomas
The results show that the elements for a local loop of α-amidated gastrins and their receptor are detectable in 80% of human gastric adenocarcinomas, and support the contention that locally expressed gastrin may be involved in the tumorigenesis of gastric cancer.