Gastric protection by meciadanol

  title={Gastric protection by meciadanol},
  author={Stanisław Jan Konturek and Mary Ellen Kitler and Tomasz Brzozowski and Tadeusz Radecki},
  journal={Digestive Diseases and Sciences},
Flavonoids reportedly inhibit histidine decarboxylase and reduce gastric mucosal histamine content. We studied the effects of acute and chronic intragastric administration to rats of meciadanol, a new synthetic flavonoid (Zyma S.A., Nyon, Switzerland). The action of meciadanol was compared to that of 16, 16-dimethyl PGE2. Meciadanol did not affect acid or pepsin output at any dose used. High doses of 16, 16-dimethyl PGE2 reduced both acid and pepsin output. Meciadanol partially prevented… 
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  • P. Guth
  • Biology
    Digestive Diseases and Sciences
  • 2005
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Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways.
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OriginatArtiele TheEffectof EpigallocatechinGallateon Intestinal Motility in Mice
The results of the present study suggest that EGCg inhibits the motility of the jejunum by direct action on smooth muscle cells where a guanytate cyclase-dependent mechanism may be partly inyolved.


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Meciadanol prevented aspirin- induced microbleeding and aspirin-induced DNA loss, suggesting that gastric mucosal histamine is involved in the mucosal injury caused by aspirin.
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The studies on the evaluation of some histidine decarboxylase inhibitors show that these compounds have a promising potential for developing an effective and safe anti-ulcer drug.
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Mobilization and formation of histamine in the gastric mucosa as related to acid secretion
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Vagotomy and histamine H2-receptor antagonists modulate histamine catabolism by histamine methyl-transferase and the implication for treatment of duodenal ulcer are discussed.
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The list of drugs which have shown a cytoprotective action in animal experiments is growing rapidly and includes zinc sulphate, meciadanol, propranolol, dipyridamole etc.
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