Gastric protection by meciadanol

@article{Konturek2005GastricPB,
  title={Gastric protection by meciadanol},
  author={Stanisław Jan Konturek and Mary Ellen Kitler and Tomasz Brzozowski and Tadeusz Radecki},
  journal={Digestive Diseases and Sciences},
  year={2005},
  volume={31},
  pages={847-852}
}
Flavonoids reportedly inhibit histidine decarboxylase and reduce gastric mucosal histamine content. We studied the effects of acute and chronic intragastric administration to rats of meciadanol, a new synthetic flavonoid (Zyma S.A., Nyon, Switzerland). The action of meciadanol was compared to that of 16, 16-dimethyl PGE2. Meciadanol did not affect acid or pepsin output at any dose used. High doses of 16, 16-dimethyl PGE2 reduced both acid and pepsin output. Meciadanol partially prevented… 
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