Corpus ID: 20864923

Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice.

@article{Blagai2009GastricPB,
  title={Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice.},
  author={A. Boban Blagai{\'c} and P. Tur{\vc}i{\'c} and V. Blagai{\'c} and M. Dubove{\vc}ak and N. Jelovac and M. Zemba and B. Radi{\'c} and T. Be{\vc}ejac and D. Stancic Rokotov and P. Sikiric},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2009},
  volume={60 Suppl 7},
  pages={
          177-81
        }
}
Previously, the gastric pentadecapeptide BPC 157, (PL 14736, Pliva) has been shown to have several beneficial effects, it exert gastroprotective, anti-inflammatory actions, stimulates would healing and has therapeutic value in inflammatory bowel disease. The present study aimed to study the effect of naloxone and BPC 157 on morphine-induced antinociceptive action in hot plate test in the mouse. It was found that naloxone and BPC 157 counteracted the morphine (16 mg/kg s.c.) - analgesia… Expand
Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157.
TLDR
Beneficial and counteracting effects of BPC 157 were obtained using the equipotent dosage in parenteral or peroral regimens, unlike the different dosage levels of aspirin, as a NSAIDs prototype, which differ by a factor of about ten. Expand
Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157
TLDR
Beneficial and counteracting effects of BPC 157 were obtained using the equipotent dosage in parenteral or peroral regimens, unlike the different dosage levels of aspirin, as a NSAIDs prototype, which differ by a factor of about ten. Expand
In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro
TLDR
BPC 157 has antidote activity in its own right against lidocaine and local anesthetics and counteracted the lidocane-induced depolarisation of HEK293 cells. Expand
BPC 157 antagonized the general anaesthetic potency of thiopental and reduced prolongation of anaesthesia induced by l-NAME/thiopental combination
TLDR
It is hypothesized that certain effects of the general anaesthetic thiopental are dependent on NO-related mechanisms, which were consequently counteracted by stable gastric pentadecapeptide BPC 157, which caused a significant antagonism of general anaesthesia produced byThiopental with a parallel shift of the dose–response curve to the right. Expand
BPC 157 counteracts QTc prolongation induced by haloperidol, fluphenazine, clozapine, olanzapine, quetiapine, sulpiride, and metoclopramide in rats
Aim: Commonly, neuroleptics and prokinetics induce a prolonged QTc interval. In this study, stable gastric pentadecapeptide BPC 157 counteracts the prolongation of the QTc interval in Wistar ratsExpand
Pentadecapeptide BPC 157 shortens duration of tetracaine- and oxybuprocaine-induced corneal anesthesia in rats
TLDR
The relationship of 0.5% tetracaine- and 0.4% oxybuprocaine-induced corneal anesthesia in rats, and pentadecapeptide BPC 157 along with nitric oxide synthase (NOS) inhibitor N(gamma)-nitro-L-arginine methyl ester (L-NAME) and/or NOS substrate L-arg inine is focused on. Expand
High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736).
  • S. Ilić, D. Drmić, +16 authors P. Sikiric
  • Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2010
TLDR
Both, the prophylactic and therapeutic benefits (intraperitoneally and intragastrically) clearly imply BPC 157 as a highly effective paracetamol antidote even against highly advanced damaging processes induced by an extreme par acetamol over-dose. Expand
Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
TLDR
BPC 157, a gastric peptide, may serve as remedy in various CNS-disorders and modulates serotonergic and dopaminergic systems, beneficially affects various behavioral disturbances that otherwise appeared due to specifically (over)stimulated/damaged neurotransmitters systems. Expand
Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye’s Stress Coping Response: Progress, Achievements, and the Future
We reviewed again the significance of the stable gastric pentadecapeptide BPC 157 as a likely mediator of Robert’s stomach cytoprotection/adaptive cytoprotection and organoprotection and as novelExpand
Endogenous opiates and behavior: 2009
This paper is the 32nd consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2009 that studied the behavioral effectsExpand
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References

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The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice.
TLDR
The stable gastric pentadecapeptide BPC 157 protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated disturbances. Expand
Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats.
TLDR
Findings indicate that pentadecapeptide BPC 157 fully interacts with the dopamine system, both centrally and peripherally, or at least, that BPC157 interferes with some steps involved in catalepsy and/or ulcer formation. Expand
Pentadecapeptide BPC 157 Interactions with Adrenergic and Dopaminergic Systems in Mucosal Protection in Stress
TLDR
The demonstration that a combined stimulation ofadrenergic and dopaminergic systems by simultaneous prophylactic application of adrenaline and bromocriptine maysignificantly reduce restraint stress lesions development provides insight for further research on the beneficial mechanism of BPC 157. Expand
Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats.
TLDR
Both im and ig administered gastric pentadecapeptide BPC 157 can apparently ameliorate acute gastric ulcer in rats and antagonize the protracted effect of acetate challenge on chronic ulcer. Expand
The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-L-arginine methyl ester and L-arginine.
TLDR
The relationships among pentadecapeptide BPC 157, the NO-system, acute alcohol intoxication, and opposed withdrawal may be important, presenting pentadescapeptides BPC157+L-NAME as a suitable alcohol antagonist. Expand
Pentadecapeptide BPC 157 attenuates chronic amphetamine-induced behavior disturbances.
TLDR
It seems that this gastric pentadecapeptide BPC 157 has a modulatory effect on dopamine system, and it could be used in chronic amphetamine disturbances. Expand
The antidepressant effect of an antiulcer pentadecapeptide BPC 157 in Porsolt's test and chronic unpredictable stress in rats. A comparison with antidepressants
TLDR
In chronic unpredictable stress procedure, particular aggravation of experimental conditions markedly affected the conventional antidepressant activity, whereas BPC 157 effectiveness was continuously present. Expand
Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats.
TLDR
In severe serotonin syndrome, gastric pentadecapeptide BPC 157 (alone, no behavioral or temperature effect) has a beneficial activity, which is likely, particular, and mostly related to a rather specific counteraction of 5-HT2A receptors phenomena. Expand
A novel pentadecapeptide, BPC 157, blocks the stereotypy produced acutely by amphetamine and the development of haloperidol-induced supersensitivity to amphetamine
TLDR
Comp compelling evidence is provided for the interaction of pentadecapeptide BPC 157 with the dopamine system, shown to attenuate different lesions and induce stereotypy in rats. Expand
Pentadecapeptide BPC 157, Cimetidine, Ranitidine, Bromocriptine, and Atropine Effect in Cysteamine Lesions in Totally Gastrectromized Rats (A Model for Cytoprotective Studies)
TLDR
These findings -- equal damaging effect of cysteamine and equal protection of pentadecapeptide BPC157 and reference agents in gastrectomized and rats with intact stomach -- seem to be particularly relevant for a cytoprotective viewpoint. Expand
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