Gastric pH Influences the Appearance of Double Peaks in the Plasma Concentration-Time Profiles of Cimetidine After Oral Administration in Dogs

Abstract

The plasma concentration-time profiles of cimetidine often exhibit two peaks following oral administration of a single dose in the fasted state, while the concurrent administration of some antacids results in a lower extent as well as rate of absorption. In the present work, absorption of cimetidine after a single dose in the fasted state was studied as a… (More)
DOI: 10.1023/A:1016284214708

Topics

Cite this paper

@article{Mummaneni1995GastricPI, title={Gastric pH Influences the Appearance of Double Peaks in the Plasma Concentration-Time Profiles of Cimetidine After Oral Administration in Dogs}, author={Vanaja Mummaneni and Gordon L Amidon and Jennifer B. Dressman}, journal={Pharmaceutical Research}, year={1995}, volume={12}, pages={780-786} }