Gastric mucosal nerve density: a biomarker for diabetic autonomic neuropathy?

  title={Gastric mucosal nerve density: a biomarker for diabetic autonomic neuropathy?},
  author={Mona M. Selim and Gwen Wendelschafer-Crabb and J. Bruce Redmon and Alexander Khoruts and James S. Hodges and Kathleen Koch and David Walk and William Robert Kennedy},
  volume={75 11},
BACKGROUND Autonomic neuropathy is a frequent diagnosis for the gastrointestinal symptoms or postural hypotension experienced by patients with longstanding diabetes. However, neuropathologic evidence to substantiate the diagnosis is limited. We hypothesized that quantification of nerves in gastric mucosa would confirm the presence of autonomic neuropathy. METHODS Mucosal biopsies from the stomach antrum and fundus were obtained during endoscopy from 15 healthy controls and 13 type 1 diabetic… CONTINUE READING


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