Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota

  title={Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota},
  author={Rui M. Ferreira and Joana Pereira-Marques and In{\^e}s Pinto-Ribeiro and Jos{\'e} Lu{\'i}s Costa and F{\'a}tima Carneiro and Jos{\'e} Carlos Machado and C{\'e}u Figueiredo},
  pages={226 - 236}
Objective Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our aim was to evaluate the composition of the gastric microbiota in chronic gastritis and in gastric carcinoma. Design The gastric microbiota was retrospectively investigated in 54… 
Alterations in mucosa-associated microbiota in the stomach of patients with gastric cancer
Different niche-specific microbiota alterations during the progression from gastritis to gastric cancer may reflect adaptions of the microbiota to the diverse specific environmental habitats in the stomach, and may play an important, as yet undetermined, role in gastric carcinogenesis.
Gastric Microbiota beyond H. pylori: An Emerging Critical Character in Gastric Carcinogenesis
Gastric cancer (GC) is one of the global leading causes of cancer death. The association between Helicobacter pylori, which is a predominant risk factor for GC, with GC development has been
The Gastric Microbiome Is Perturbed in Advanced Gastric Adenocarcinoma Identified Through Shotgun Metagenomics
The results present new alterations in the gastric microbiome in patients with GC from a whole-genome perspective, suggesting that microbiome composition and function can be used for prognosis and diagnosis of GC.
Dysbiotic change in gastric microbiome and its functional implication in gastric carcinogenesis
There are significant changes in the diversity and composition of gastric microbiome during the gastric carcinogenesis process, and predictive analysis of the functional capacity of the microbiome suggested enrichment or depletion of several functional pathways related to carcinogenesis in the cancer group.
Gastrointestinal Microbiota Changes in Patients With Gastric Precancerous Lesions
Analysis of microbial sequences revealed decreased bacterial alpha diversity in gastric bacteria during the progression of gastritis and the microbial model of H. pylori-positive gastric biopsies and feces showed value in the prediction of gastric precancerous lesions.
Alterations of Gastric Microbiota in Gastric Cancer and Precancerous Stages
The results provide insights on potential taxonomic biomarkers for gastric cancer and precancerous stages, and suggest that gastric microbiota might play different roles in the carcinogenesis of cardia cancer and non-cardia cancer.
Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer
It is revealed that the dysbiotic microbiota in H. pylori positive mucosa was associated with advanced gastric lesions and could be reversed by eradication and shows beneficial effects on gut microbiota.
The Effects of Helicobacter pylori Infection on Microbiota Associated With Gastric Mucosa and Immune Factors in Children
The presence of Helicobacter pylori significantly influences gastric microbiota and results in lower abundance of multiple taxonomic levels in children, Meanwhile, it affects gastric immune environment and promotes the occurrence of gastritis.
Helicobacter pylori Infection, the Gastric Microbiome and Gastric Cancer.
This chapter summarizes what is known about the gastric microbiome in the context of H. pylori-associated gastric cancer, introducing the emerging dimension of the microbiome into the pathogenesis of this highly incident and deadly disease.
Association Between Gut Microbiota and Helicobacter pylori-Related Gastric Lesions in a High-Risk Population of Gastric Cancer
The findings suggest that the alterations of fecal microbiota, especially the dominant phyla of Bacteroidetes, Firmicutes and Proteobacteria, may be involved in the process of H. pylori-related gastric lesion progression and provide hints for future evaluation of microbial changes after H.pylori eradication.


Molecular Characterization of the Human Stomach Microbiota in Gastric Cancer Patients
It was showed that Hp is the dominant member of the non-malignant gastric tissue microbiota in many gastric cancer patients, and taxonomic and derived functional profiles of gastric microbiota were distinct from those found in other body sites and had higher inter-subject dissimilarity.
Molecular characterization of the stomach microbiota in patients with gastric cancer and in controls.
The gastric microbiota from ten patients with gastric cancer was characterized and compared with that from five dyspeptic controls using the molecular profiling approach terminal restriction fragment length polymorphism (T-RFLP), in combination with 16S rRNA gene cloning and sequencing, which revealed a complex bacterial community in the cancer patients that was not significantly different from that in the controls.
Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia
The gastric microbiota composition was highly variable between individuals, but showed a significant correlation with the town of origin, and testable hypotheses can be generated and examined in suitable animal models and prospective clinical trials.
Bacterial Microbiota Profiling in Gastritis without Helicobacter pylori Infection or Non-Steroidal Anti-Inflammatory Drug Use
It is suggested that the genus taxon level can largely represent much higher taxa such as the phylum within the Firmicutes phylum, as observed in patients with antral gastritis, compared with normal controls.
Mucosal microbiome dysbiosis in gastric carcinogenesis
Differences in bacterial interactions across stages of gastric carcinogenesis are identified and significant enrichments and network centralities suggest potentially important roles of P. pneumosintes, S. exigua, P. stomatis, D. micra and S. anginosus in GC progression.
The active bacterial assemblages of the upper GI tract in individuals with and without Helicobacter infection
Detailed analysis of the active global bacterial communities from the five distinct sites of the upper GI tract allowed for the first time the differentiation between host effects and the influence of sampling region on the bacterial community.
Molecular analysis of the bacterial microbiota in the human stomach.
  • E. Bik, P. Eckburg, D. Relman
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
Bacterial diversity within the human gastric mucosa was characterized by using a small subunit 16S rDNA clone library approach and sequences generated by broad-range bacterial PCR from 23 gastric endoscopic biopsy samples were analyzed, featuring diversity at this site greater than previously described.
Structure of the human gastric bacterial community in relation to Helicobacter pylori status
The PhyloChip detected richness of low abundance phyla, and showed marked differences in the structure of the gastric bacterial community according to H. pylori status.
Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer
This study is the first to show a gradual shift in gastric microbiota profile from NAG to IM to GC, and it is revealed that GC and NAG grouped apart, whereas IM overlapped with both.
Microbiological Survey of the Human Gastric Ecosystem Using Culturing and Pyrosequencing Methods
This is the first study in which a combination of culture and culture-independent techniques has been used to explore the bacterial diversity of the human stomach, revealing wide bacterial diversity.