Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota

@article{Ferreira2018GastricMC,
  title={Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota},
  author={Rui Manuel Ferreira and Joana Pereira-Marques and In{\^e}s Pinto-Ribeiro and Jos{\'e} Lu{\'i}s Costa and F{\'a}tima Carneiro and Jos{\'e} Carlos Machado and C{\'e}u Figueiredo},
  journal={Gut},
  year={2018},
  volume={67},
  pages={226 - 236}
}
Objective Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our aim was to evaluate the composition of the gastric microbiota in chronic gastritis and in gastric carcinoma. Design The gastric microbiota was retrospectively investigated in 54… 
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References

SHOWING 1-10 OF 53 REFERENCES
Molecular characterization of the stomach microbiota in patients with gastric cancer and in controls.
TLDR
The gastric microbiota from ten patients with gastric cancer was characterized and compared with that from five dyspeptic controls using the molecular profiling approach terminal restriction fragment length polymorphism (T-RFLP), in combination with 16S rRNA gene cloning and sequencing, which revealed a complex bacterial community in the cancer patients that was not significantly different from that in the controls.
Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia
TLDR
The gastric microbiota composition was highly variable between individuals, but showed a significant correlation with the town of origin, and testable hypotheses can be generated and examined in suitable animal models and prospective clinical trials.
Bacterial Microbiota Profiling in Gastritis without Helicobacter pylori Infection or Non-Steroidal Anti-Inflammatory Drug Use
TLDR
It is suggested that the genus taxon level can largely represent much higher taxa such as the phylum within the Firmicutes phylum, as observed in patients with antral gastritis, compared with normal controls.
Mucosal microbiome dysbiosis in gastric carcinogenesis
TLDR
Differences in bacterial interactions across stages of gastric carcinogenesis are identified and significant enrichments and network centralities suggest potentially important roles of P. pneumosintes, S. exigua, P. stomatis, D. micra and S. anginosus in GC progression.
The active bacterial assemblages of the upper GI tract in individuals with and without Helicobacter infection
TLDR
Detailed analysis of the active global bacterial communities from the five distinct sites of the upper GI tract allowed for the first time the differentiation between host effects and the influence of sampling region on the bacterial community.
Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer
TLDR
This study is the first to show a gradual shift in gastric microbiota profile from NAG to IM to GC, and it is revealed that GC and NAG grouped apart, whereas IM overlapped with both.
Microbiological Survey of the Human Gastric Ecosystem Using Culturing and Pyrosequencing Methods
TLDR
This is the first study in which a combination of culture and culture-independent techniques has been used to explore the bacterial diversity of the human stomach, revealing wide bacterial diversity.
Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis
TLDR
RASFHp colonisation was sufficient for GIN development in males, and lower GIN incidence in females was associated with lower inflammatory responses and gastric commensal and Hp Colonisation, supporting that Hp infection accelerates gastric cancer development in INS-GAS mice.
Human gut microbiome and risk for colorectal cancer.
TLDR
It is found that CRC case subjects had decreased overall microbial community diversity and lower relative abundance of Clostridia and increased carriage of Fusobacterium were found in case subjects compared with control subjects.
The first 1000 cultured species of the human gastrointestinal microbiota
TLDR
This review provides a systematic overview and detailed references of the total of 1057 intestinal species of Eukarya, Archaea and Bacteria based on the phylogenetic framework of their small subunit ribosomal RNA gene sequences and unifies knowledge about the prevalence, abundance, stability, physiology, genetics and the association with human health of these gastrointestinal microorganisms.
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