Gastric juice: a barrier against infectious diseases.

  title={Gastric juice: a barrier against infectious diseases.},
  author={Tom Christian Martinsen and K{\aa}re Bergh and H L Waldum},
  journal={Basic & clinical pharmacology & toxicology},
  volume={96 2},
All vertebrates produce gastric acid. Its main function is inactivation of ingested microorganisms. The majority of microbiological pathogens ingested never reaches the intestine because of the gastric barrier. Although gastric hypochlorhydria is fairly common due to atrophic gastritis, gastric surgery or use of inhibitors of gastric acid secretion, the resulting susceptibility to infection has not been studied extensively. Drug-induced blockade of acid secretion leads to gastrointestinal… CONTINUE READING
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