Gastric antisecretory and antiulcer effects of simvastatin in rats.

  title={Gastric antisecretory and antiulcer effects of simvastatin in rats.},
  author={Mohammad Tariq and Haseeb Ahmad Khan and Ibrahim Elfaki and Mohammad Arshaduddin and Meshal Al Moutaery and Hannan Al Rayes and Ramiz Al Swailam},
  journal={Journal of gastroenterology and hepatology},
  volume={22 12},
BACKGROUND AND AIM Recently, statins have appeared to have additional benefits beyond their lipid lowering effects, which has led to the interest in the use of this class of drugs outside the realm of cardiovascular disease. Simvastatin (SIM) is a commonly prescribed statin with anti-inflammatory and antioxidant properties. Excessive generation of oxygen-derived free radicals (ODFR) and proinflammatory mediators has been implicated in the pathogenesis of gastric ulcers. This investigation aimed… CONTINUE READING