Gastric and cardiovascular effects of histamine in the dog

  title={Gastric and cardiovascular effects of histamine in the dog},
  author={B. Hirschowitz and J. Rentz and E. Molina and A. Waldo},
  journal={Agents and Actions},
  • B. Hirschowitz, J. Rentz, +1 author A. Waldo
  • Published 2005
  • Chemistry, Medicine
  • Agents and Actions
  • The H-2 receptor stimulation of gastric acid secretion and of heart rate by histamine, a mixed H-1–H-2 agonist, given in 45-min successive step doses 2–150 μg base/kg.h and 4(Me)histamine, (4(Me)H), 1.4 to 210 μg base/kg.h, a specific H-2 agonist, in five conscious gastric fistula dogs showed no difference between the agonists in ED50s or in maximal responses. The ED50 for acid was lower (15–16 μg/kg.h) than for cardiac chronotropism (25 to 27 μg/kg.h). Both effects were competitively… CONTINUE READING


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