Gastric and cardiac H-2 receptor effects of dimaprit and N'(Me),5(Me)histamine in conscious dogs.

@article{Hirschowitz1980GastricAC,
  title={Gastric and cardiac H-2 receptor effects of dimaprit and N'(Me),5(Me)histamine in conscious dogs.},
  author={B. Hirschowitz and J. Rentz and E. Molina},
  journal={European journal of pharmacology},
  year={1980},
  volume={61 4},
  pages={
          355-61
        }
}
  • B. Hirschowitz, J. Rentz, E. Molina
  • Published 1980
  • Chemistry, Medicine
  • European journal of pharmacology
  • Two new H-2 agonists 5,N'-dimethyl histamine (DMH), an imidazole analog, and dimaprit, a non-imidazole compound, and histamine (H), a mixed H-1, H-2 agonist, were given to four conscious gastric fistula dogs. Gastric acid was stimulated dose responsively. Dimaprit stimulated a 20% greater maximum output of acid, and more pepsin than the other agents, but inhibited pepsin secretion as doses of greater than 0.63 mumol/kg-h. Heart rate was increased dose responsively by all drugs to approximately… CONTINUE READING
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