Gastric Toxicity and Prostaglandin Content in Rats Dosed with Two Chemically Similar, Nonsteroidal Anti-Inflammatory Agents

  title={Gastric Toxicity and Prostaglandin Content in Rats Dosed with Two Chemically Similar, Nonsteroidal Anti-Inflammatory Agents},
  author={Robert R. Brooks and Thomas John Moorehead and Schwe Fang Pong},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={233 - 238}
Abstract Two chemically similar nonsteroidal anti-inflammatory drugs, orpanoxin and F-1067, had almost identical potencies and efficacies as anti-inflammatory (rat paw edema) and analgesic (mouse writhing) agents, but differed markedly in gastrotoxicity. Orpanoxin alone aggravated stomach lesions in rats subjected to pylorus ligation and failed to protect stomachs of rats challenged with indomethacin. The compounds did not differ in their in vitro enzyme inhibition effects, both failing to… 
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