Gastric M1 mucin, an early oncofetal marker of colon carcinogenesis, is encoded by the MUC5AC gene.

@article{Bara1998GastricMM,
  title={Gastric M1 mucin, an early oncofetal marker of colon carcinogenesis, is encoded by the MUC5AC gene.},
  author={Jacques Bara and Eric Chastre and J{\'e}r{\^o}me Mahiou and Ram Lakhan Singh and Marie-Elizabeth Forgue-Lafitte and Etienne Hollande and François Godeau},
  journal={International journal of cancer},
  year={1998},
  volume={75 5},
  pages={
          767-73
        }
}
Gastric M1 mucin and the MUC5AC gene show a similar oncofetal expression in the colon. Our aim was to determine whether M1 mucin is the product of the MUC5AC gene. A recombinant baculovirus encoding the C-terminal portion of the MUC5AC gene as a fusion protein was isolated and the immunoreactivity of the recombinant mucin (rM) toward M1 antibodies studied. Chicken antibodies also were raised against purified rM. Besides its reactivity with L56/C, a serum recognizing the bacterially expressed… CONTINUE READING
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