Gastric Carcinoids and Neuroendocrine Carcinomas: Pathogenesis, Pathology, and Behavior

@article{Rindi1996GastricCA,
  title={Gastric Carcinoids and Neuroendocrine Carcinomas: Pathogenesis, Pathology, and Behavior},
  author={Guido Rindi and Cesare Bordi and Sigrid Rappel and Stefano La Rosa and Manfred Stolte and Enrico Solcia},
  journal={World Journal of Surgery},
  year={1996},
  volume={20},
  pages={168-172}
}
Abstract. The goal of this study was to provide information of prognostic value for gastric endocrine tumors. A total of 205 gastric endocrine tumors have been studied: 193 well differentiated tumors [2 gastrin cell tumors, 191 enterochromaffin-like (ECL) cell tumors] and 12 poorly differentiated carcinomas. Subtyping of ECL cell tumors (carcinoids) resulted in 152 associated with chronic atrophic gastritis (CAG) (type 1); 12 associated with hypertrophic gastropathy (HG) due to Zollinger… Expand
Prognostic value of immunohistochemistry in gastric neuroendocrine (carcinoid) tumors
Three subtypes of enterochromaffin-like cell tumors (carcinoids) have been described: type I, associated with chronic atrophic gastritis; type II, multiple endocrine neoplasia 1 and Zollinger–EllisonExpand
Natural history, clinicopathologic classification and prognosis of gastric ECL cell tumors.
TLDR
Investigation of a larger tumor series is under way with the aim of developing an optimal model for prognostic evaluation of gastric endocrine tumors to predict tumor malignancy. Expand
Classification of gastric neuroendocrine tumors and its clinicopathologic significance.
TLDR
A correct identification of different types of gastric endocrine tumors has major implications for the treatment and prognosis of the patients. Expand
ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: prognostic evaluation by pathological analysis.
TLDR
Criteria for the assessment of malignancy risk and patient outcome were developed for the different tumors, providing a basis for treatment guidelines. Expand
Gastric carcinoids: Review a propos of two cases
TLDR
It is demonstrated that classification of these tumours is not always straightforward and the importance of extensive endoscopic sampling in the setting of multiple gastric polypoid lesions is highlighted. Expand
A Clinical Perspective on Gastric Neuroendocrine Neoplasia
TLDR
The incidence of gastric neuroendocrine tumors has increased exponentially based on widespread use of endoscopy and a greater pathological awareness of the condition and elucidation of the precise biology of a gastric NET is critical to diagnosis and delineation of a type-specific management strategy. Expand
Neuroendocrine Neoplasms of the Stomach
TLDR
The treatment of advanced G-NETs needs to be multimodal and best accomplished in subspecialty referral centers with advanced clinical, pathologic, and imaging expertise, in order to succeed with more personalized patient management strategies. Expand
Typical carcinoids and neuroendocrine carcinomas of the stomach: differing clinical courses and prognoses.
TLDR
Regardless of the type, carcinoids that are not yet advanced can be effectively treated with minimal endoscopic or laparoscopic surgery, however, all NECs and advanced carcinoids should be treated with radical gastrectomy. Expand
Gastric neuroendocrine tumors: Biology and management
TLDR
Little progress has been made in the treatment of the rare, highly malignant, poorly differentiated neuroendocrine carcinomas, which are rapidly fatal, showing only short-lived responses to chemotherapy. Expand
Morphological, molecular, and prognostic aspects of gastric endocrine tumors
TLDR
The large majority of gastric neuroendocrine tumors is made by benign, gastrin‐dependent, well‐differentiated ECL cell growths arising in a background of chronic atrophic gastritis or associated with type I multiple endocrine neoplasia and Zollinger‐Ellison syndromes. Expand
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References

SHOWING 1-10 OF 34 REFERENCES
Clinicopathologic aspects of gastric neuroendocrine tumors.
  • G. Rindi
  • Medicine
  • The American journal of surgical pathology
  • 1995
TLDR
It is concluded that type 1 and type 2 well-differentiated ECL tumors are benign or low-grade tumors, whereas type 3 well- differentiated EL tumors and the poorly differentiated neuroendocrine carcinomas are malignant neoplasms. Expand
Gastric carcinoids and related endocrine growths.
TLDR
A series of 30 gastric endocrine tumours has been revised in the light of available available cytologic and clinicopathologic information, and hypergastrinaemia is among causative agents of argyrophil ECL cell hyperplasias and, possibly, of tumours of the oxynticopeptic mucosa. Expand
Distinct patterns of chronic gastritis associated with carcinoid and cancer and their role in tumorigenesis.
TLDR
Primary hypergastrinemia and local mechanisms activated by chronic autoimmune gastritis are among factors involved in the pathogenesis of relatively indolent CAG-associated carcinoids, whereas active HP gastritis in cooperation with environmental carcinogens may likely cause more severe epithelial transformation, leading to ordinary cancer and, possibly, to neuroendocrine carcinomas or mixed endocrine-exocrine tumors. Expand
Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study.
TLDR
Gastrin-promoted carcinoids represent a benign or low grade tumor disease, whereas sporadic carcinoids and neuroendocrine carcinomas are life-threatening neoplasms, independent of gastrin promotion. Expand
Prognosis of gastric carcinoid tumours.
TLDR
It is concluded that, depending upon the subtype involved, the prognosis of gastric carcinoid tumours varies, such that regular endoscopy/biopsy follow-up suffices for patients with type A gastritis, while for Patients with sporadic carcinoids tumours, surgical treatment is indicated. Expand
Gastric carcinoids and their precursor lesions. A histologic and immunohistochemical study of 23 cases
TLDR
A histologic and immunohistochemical study was carried out in 23 unselected nonantral gastric carcinoids and their precursor lesions and the results are of relevance for tumor pathogenesis and may provide the rationale for a less aggressive therapeutic approach in the patients. Expand
Small cell carcinoma of the stomach: a clinicopathologic study of 17 cases.
TLDR
Findings suggest that histologic variety is quite characteristic of the small cell carcinomas of the stomach, and this type of carcinoma takes an aggressive clinical course like its counterparts in other organs. Expand
Gastroscopic screening for gastric carcinoids and carcinoma in pernicious anemia.
TLDR
Even though most gastric carcinoids are small subclinical tumors of uncertain clinical significance, their unexpectedly high frequency, combined within the risk of carcinoma in PA, might indicate the need for gastroscopic follow-up, at least in cases of juvenile onset PA. Expand
Histopathological classification of nonantral gastric endocrine growths in man.
TLDR
A definition of nonantral gastric endocrine hyperplasia, dysplasia (enlarging or fusing micronodules, microinvasion, nodular growth) and neoplasia (intramucosal carcinoid, invasive carcinoid) is presented. Expand
Morphology and pathogenesis of endocrine hyperplasias, precarcinoid lesions, and carcinoids arising in chronic atrophic gastritis.
TLDR
The spectrum of endocrine cell changes occurring in 80 cases of body-fundus chronic atrophic gastritis, including various types of hyperplasia, precarcinoid lesions, and neoplasia, have been analyzed histologically, histochemically, and ultrastructurally. Expand
...
1
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3
4
...