Gases as neurotransmitters.

  title={Gases as neurotransmitters.},
  author={Jane E Haley},
  journal={Essays in biochemistry},
NO and CO are small gaseous molecules that can be synthesized de novo in neuronal tissue and can diffuse readily through the plasma membrane. NOS inhibitors prevent the induction of LTP in the hippocampus, and studies with NOS knock-out mice and viral overexpression of mutated NOS indicate that the endothelial form of the enzyme is probably responsible for NO production in these neurons. Inhibitors of CO production can block the induction of LTP, but this does not correlate with their ability… CONTINUE READING


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