Gaseous messengers in oxygen sensing

  title={Gaseous messengers in oxygen sensing},
  author={Nanduri R Prabhakar and Gregg L Semenza},
  journal={Journal of Molecular Medicine},
The carotid body is a sensory organ that detects acute changes in arterial blood oxygen (O2) levels and reflexly mediates systemic cardiac, vascular, and respiratory responses to hypoxia. This article provides a brief update of the roles of gas messengers as well as redox homeostasis by hypoxia-inducible factors (HIFs) in hypoxic sensing by the carotid body. Carbon monoxide (CO) and nitric oxide (NO), generated by heme oxygenase-2 (HO-2) and neuronal nitric oxide synthase (nNOS), respectively… CONTINUE READING


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