Gaseous formaldehyde and hydrogen chloride induction of nasal cancer in the rat.

  title={Gaseous formaldehyde and hydrogen chloride induction of nasal cancer in the rat.},
  author={Roy E. Albert and Arthur R. Sellakumar and S E Laskin and M. Kuschner and Norton Nelson and Carroll A. Snyder},
  journal={Journal of the National Cancer Institute},
  volume={68 4},
The carcinogenic response to the combined and separate exposures to formaldehyde (HCHO) and hydrochloric acid (HCl) was investigated in male inbred SD rats. The rats were exposed to gaseous HCHO, 14 ppm, and HCl, 10 ppm, in two experiments. In one experiment the gases were premixed at high concentrations before being diluted in the exposure chamber air to maximize the formation of the carcinogen bis(chloromethyl)ether (BCME). In the second experiment exposure was repeated to HCl and HCHO… CONTINUE READING
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Kinetic studies of bis ( chloromethyl ) ether hydrolysis by mass spectrometry

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