Gas6 induces mesangial cell proliferation via latent transcription factor STAT3.

@article{Yanagita2001Gas6IM,
  title={Gas6 induces mesangial cell proliferation via latent transcription factor STAT3.},
  author={Motoko Yanagita and Hidenori Arai and Toru Nakano and Kazuyo Ohashi and Kouichi Mizuno and Atsushi Fukatsu and Toshio Doi and Toru Kita},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 45},
  pages={42364-9}
}
Mesangial cell proliferation is essential for the pathogenesis and progression of glomerular disease. Previously, we showed that Gas6 plays a pivotal role in mesangial cell proliferation in vitro and in vivo. In the present study, we identified downstream targets of Gas6 signaling to examine the role in mesangial cell proliferation in vitro and in vivo. We found that Gas6 tyrosine phosphorylates STAT3 (signal transducers and activators of transcription) with concomitant translocation to the… CONTINUE READING