Gas6 and protein S

@article{Hafizi2006Gas6AP,
  title={Gas6 and protein S},
  author={S. Hafizi and B. Dahlb{\"a}ck},
  journal={The FEBS Journal},
  year={2006},
  volume={273}
}
Gas6 and protein S are two homologous secreted proteins that depend on vitamin K for their execution of a range of biological functions. A discrete subset of these functions is mediated through their binding to and activation of the receptor tyrosine kinases Axl, Sky and Mer. Furthermore, a hallmark of the Gas6–Axl system is the unique ability of Gas6 and protein S to tether their non receptor‐binding regions to the negatively charged membranes of apoptotic cells. Numerous studies have shown… Expand
TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis
TLDR
To comprehend the effects that the TAM receptors and their ligands have on hemostasis and inflammation, studies that report the different phenotypes displayed by mice with deficiencies in the genes of this receptor family and its ligands are compared. Expand
Growth arrest-specific gene 6 (gas6) and vascular hemostasis.
TLDR
The role of gas6 in innate immunity, atherosclerosis, thrombosis, and cancer-related events, and the mechanism in thrombus occurrence is focused on. Expand
Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine.
TLDR
A heretofore unknown function of Gla is proposed, where Gla-PS binding on the N-terminus of gas6 is necessary for a gas6 function mediated through its binding to Axl via its C-terminal domain. Expand
: VITAMIN K Growth Arrest-Speci fi c Gene 6 ( gas 6 ) and Vascular Hemostasis 1 , 2
Gas6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. Gas6 has a high structural homology with the natural anticoagulant protein S, sharing theExpand
Vitamin K‐Dependent Protein S: Beyond the Protein C Pathway
  • B. Dahlbäck
  • Biology, Medicine
  • Seminars in thrombosis and hemostasis
  • 2018
TLDR
The multiple functions of protein S are discussed, describing its role as cofactor to activated protein C with a subsequent focus on the other functions ofprotein S. Expand
Modulation of protein S and growth arrest specific 6 protein signaling inhibits pancreatic cancer cell survival and proliferation
TLDR
It was revealed that PS-TAM interaction was pro-apoptotic, whereas GAS6-mediated TAM signaling promoted proliferation and survival in select PDAC cell lines, and by regulating the balance between these two signaling pathways, the proliferative potential of the cells was decreased. Expand
Inhibitory role of Gas6 in intestinal tumorigenesis.
TLDR
A unique in vivo inhibitory role of Gas6 is revealed during the progression of intestinal tumors associated with suppression of stromal immune reactions, suggesting a novel therapeutic approach for colorectal cancer patients by regulation of stromaal immune responses. Expand
Axl-dependent signalling: a clinical update.
TLDR
Current challenges in Axl biology are related to the functional interactions of Axl with other members of the TAM family or other tyrosine kinases, mechanisms of ligand-independent activation, inactivation of the receptor and cell-cell interactions (with respect to immune cells) in chronic diseases. Expand
Role of Tyro3, Axl, and Mer Receptors and Their Ligands (Gas6, and Protein S) in Patients with Hepatocellular Carcinoma
TLDR
Through the progression of HCC, Axl played the major role in TAMRs activation, and sTYro3 continued increasing rapidly from the early stage, and that of Mer increased throughout the progression. Expand
Inhibitory role of Gas 6 in intestinal tumorigenesis
Growth arrest-specific gene (Gas) 6 is a γ-carboxyglutamic acid domain-containing protein, which shares 43% amino acid identity with protein S. Gas6 has been shown to enhance cancer cellExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 125 REFERENCES
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
TLDR
The identification of ligands for Tyro 3 and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases, correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related toprotein S but lacking any known function. Expand
Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.
TLDR
This article reviews the knowledge so far on the intracellular signalling interactions and pathways concerning each of the Axl RTKs to gain a greater understanding of the mechanisms that set each of them apart, and that relay their associated functions. Expand
Structural basis for Gas6–Axl signalling
TLDR
Structural‐based mutagenesis, protein binding assays and receptor activation experiments demonstrate that both the major and minor Gas6 binding sites are required for productive transmembrane signalling. Expand
Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation
TLDR
Gas6, the product of a growth arrest specific gene, is identified as a ligand for Mer, an orphan receptor tyrosine kinase expressed at high levels in monocytes and cells derived from epithelial and reproductive tissues. Expand
Characterization of Gas6, a Member of the Superfamily of G Domain-containing Proteins, as a Ligand for Rse and Axl (*)
TLDR
Results provide evidence that G domains can act as signaling molecules by activating transmembrane receptor tyrosine kinases and provide a structural link between the activation of cell adhesion related receptors and the control of cell growth and differentiation by the G domain-containing superfamily of proteins. Expand
Vitamin K-Dependent Protein S Localizing Complement Regulator C4b-Binding Protein to the Surface of Apoptotic Cells1
TLDR
The C4BP that was bound via protein S to the apoptotic cells was able to interact with the complement protein C4b, supporting a physiological role of the C4 BP/protein S complex in regulation of complement on the surface of apoptotic cell surface. Expand
Coexpression of Gas6/Axl in Human Ovarian Cancers
TLDR
The histoscores and mRNA levels of Gas6 and Axl in ovarian cancers were significantly higher than in normal ovaries, regardless of histopathological type or clinical stage of ovarian cancers. Expand
Stimulation of Sky tyrosine phosphorylation by bovine protein S--domains involved in the receptor-ligand interaction.
TLDR
The results indicate that protein S might be a ligand of Sky in some species despite the lack of activity of human protein S on human Sky, and the bovine/human protein S species difference will be a useful model to establish the structural requirements for the interaction between Sky and its ligands. Expand
A novel site contributing to growth-arrest-specific gene 6 binding to its receptors as revealed by a human monoclonal antibody.
TLDR
A neutralizing human monoclonal antibody, named CNTO300, was developed and revealed, for the first time, a second binding site for Gas6-receptor interaction. Expand
Crystal Structure of a C-terminal Fragment of Growth Arrest-specific Protein Gas6
TLDR
It is shown that mutagenesis of some residues in this patch reduces Gas6-LG binding to the extracellular domain of Axl as well as Axl activation in glioblastoma cells, identifying a component of the receptor-binding site of Gas6. Expand
...
1
2
3
4
5
...