Gas1 interferes with AβPP trafficking by facilitating the accumulation of immature AβPP in endoplasmic reticulum-associated raft subdomains.

@article{Chapuis2012Gas1IW,
  title={Gas1 interferes with AβPP trafficking by facilitating the accumulation of immature AβPP in endoplasmic reticulum-associated raft subdomains.},
  author={Julien Chapuis and Val{\'e}rie Vingtdeux and Hemachander Capiralla and Peter Davies and Philippe Marambaud},
  journal={Journal of Alzheimer's disease : JAD},
  year={2012},
  volume={28 1},
  pages={127-35}
}
The amyloid-β protein precursor (AβPP) is a type I transmembrane protein that undergoes maturation during trafficking in the secretory pathway. Proper maturation and trafficking of AβPP are necessary prerequisites for AβPP processing to generate amyloid-β (Aβ), the core component of Alzheimer's disease senile plaques. Recently, we reported that the glycosylphosphatidylinositol (GPI)-anchored protein growth arrest-specific 1 (Gas1) binds to and interferes with the maturation and processing of A… CONTINUE READING

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Expression of Gas1 in Mouse Brain: Release and Role in Neuronal Differentiation

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Growth arrest specific 1 (GAS1) is abundantly expressed in the adult mouse central nervous system.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society • 2013
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