Gas-phase conformations of capistruin - comparison of lasso, branched-cyclic and linear topologies.

RATIONALE Capistruin is a peptide synthesized by Burkholderia thailandensis E264, which displays a lasso topology. This knot-like structure confers interesting properties to peptides (e.g. antibacterial). Therefore, it is important to evaluate the sensitivity of structural characterization methods to such topological constraints. METHODS Ion mobility mass… CONTINUE READING