Gas-liquid chromatographic method for the determination of tolperisone in human plasma: pharmacokinetic and comparative bioavailability studies.

@article{Miskolczi1987GasliquidCM,
  title={Gas-liquid chromatographic method for the determination of tolperisone in human plasma: pharmacokinetic and comparative bioavailability studies.},
  author={P. Miskolczi and L. Vereczkey and R. Frenkl},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1987},
  volume={5 7},
  pages={
          695-700
        }
}
A new capillary GLC method for the determination of tolperisone in human plasma was developed. Pharmacokinetic and comparative bioavailability studies were carried out after i.v. administration and after oral administration of two different preparations of tolperisone. After i.v. administration of the drug the elimination half-life was found to be 1.55 +/- 0.7 h (mean +/- S.D.), the apparent volume of distribution to be 5.1 +/- 1.0 l/kg (mean +/- S.D.) and total body clearance to be 140.8… Expand
HPLC Determination of tolperisone in human plasma
Determination of tolperisone in human plasma by liquid chromatography/tandem mass spectrometry for clinical application.
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