Gas chromatography-mass spectrometry method for determination of metoprolol in the patients with hypertension.

@article{Ylmaz2009GasCS,
  title={Gas chromatography-mass spectrometry method for determination of metoprolol in the patients with hypertension.},
  author={Bilal Yılmaz and S. Cakici Arslan and Vedat Akba},
  journal={Talanta},
  year={2009},
  volume={80 1},
  pages={
          346-51
        }
}
A sensitive and efficient method was developed for determination of metoprolol in human plasma by gas chromatography-mass spectrometry (GC-MS). Metoprolol and atenolol (internal standard, IS) were extracted from human plasma with a mixture of ethylacetate and diethylether at basic pH with liquid-liquid extraction. Calibration curves were linear over the concentration range 15-500 ng/ml. Intra- and inter-day precision values for metoprolol in human plasma were less than 6.4, and accuracy… CONTINUE READING
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