Gas chromatography-mass spectrometry assay method for the therapeutic drug monitoring of the antiepileptic drug tiagabine.

@article{Chollet1999GasCS,
  title={Gas chromatography-mass spectrometry assay method for the therapeutic drug monitoring of the antiepileptic drug tiagabine.},
  author={Daniel F Chollet and Eva Castell{\`a} and L Goumaz and G Anderegg},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1999},
  volume={21 3},
  pages={641-6}
}
A gas chromatography-mass spectrometry assay method suitable for the therapeutic drug monitoring of the antiepileptic drug tiagabine is described. Tiagabine and its desmethylated analogue used as internal standard were first extracted from serum by liquid-liquid extraction using an ethyl ether-isobutanol 98:2 mixture. Tiagabine and the internal standard were then methylated in the organic phase in presence of methanol by means of a safe and stable diazomethane derivative. After evaporation, the… CONTINUE READING

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